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Uridine CAS：58-96-8
Uridine (1-β-D-Ribofuranosyluracil) is a critical pyrimidine nucleoside raw material manufactured via bio-fermentation. Our factory produces industrial, pharmaceutical USP/EP and lab standard grades with strict impurity control. Widely applied in antiviral drug intermediates, cell culture media, infant formula nucleotide additives and mRNA research substrates. We support flexible packaging from 1kg foil bags to 25kg fiber drums, offer third-party testing documents and customized batch purity for global biotech, pharma and food manufacturers.
Bulk Uridine (CAS 58-96-8) Quick Fact Sheet & Sourcing Specifications
Product Specs
Complete Uridine Technical Specifications & Quality Standards
| Item | Standard Parameter |
|---|---|
| Chemical Name | Uridine / 1-β-D-Ribofuranosyluracil |
| CAS Number | 58-96-8 |
| EINECS | 200-407-5 |
| Molecular Formula | C9H12N2O6 |
| Molecular Weight | 244.20 |
| Appearance | White crystalline powder, odorless, slight sweet taste |
| Optical Rotation | [α]D20 = +8.4° (2% aqueous solution) |
| Melting Point | 163–167°C |
| Water Solubility | 50mg/mL clear solution at 25°C; slightly soluble in methanol, insoluble in ethanol, acetone, ether |
| Aqueous pH (5% solution) | 4.0–6.0 |
Three Grade Quality Control Index (HPLC Test Standard)
1. Industrial Biochemical Grade (≥98% HPLC)
- Assay: ≥98.0%
- Loss on drying: ≤0.5%
- Residue on ignition: ≤0.1%
- Heavy metal (Pb): ≤10ppm
- Impurities: Single unknown ≤0.3%, Total ≤2.0%
2. USP/EP Pharmaceutical Grade (99.0–101.0%)
- Moisture: ≤0.3% | Ignition residue: ≤0.05%
- Purity Controls: Total heavy metals ≤5ppm, Arsenic ≤2ppm
- Specific Impurities: Uracil ≤0.1%, Pseudouridine ≤0.5%, Single related substance ≤0.1%
- Injection Ready: Endotoxin ≤0.5EU/mg
- Transmittance: ≥95% at 430nm (5% aqueous solution)
3. Research Standard Grade (≥99.8%)
- Calibration Grade: Double calibrated via HPLC & NMR
- Moisture: ≤0.1%
- Impurities: No detectable unknown impurities
- Application: Perfect for laboratory quantification and calibration standards
Microbial Fermentation Production Process & Advantages
Our Uridine adopts advanced microbial fermentation production instead of total chemical synthesis. This eco-friendly bio-tech process fundamentally reduces toxic solvent residues, significantly lowers single impurity content, and easily meets strict international pharmaceutical raw material access standards.
✔ Fully independent purification, recrystallization, and drying workshops.
✔ Each batch passes 7 rigorous internal testing procedures before factory release.
✔ 3rd-party independent purity testing (SGS / Intertek) available upon customer request.
Bulk Procurement Logistics & Storage Details
📦 Packaging Options
• 1kg vacuum aluminum foil bag
• 5kg secure inner PE bag
• 25kg industrial fiber drum with double PE liner
• 1kg vacuum aluminum foil bag
• 5kg secure inner PE bag
• 25kg industrial fiber drum with double PE liner
🆖 Storage Requirement
• Store in a sealed, light-proof, cool and dry warehouse under 25°C.
• High-purity lab grades must be stored under 2–8°C refrigeration.
• Store in a sealed, light-proof, cool and dry warehouse under 25°C.
• High-purity lab grades must be stored under 2–8°C refrigeration.
🚚 Transport & Shelf Life
• Classification: Non-hazardous general cargo.
• Avoid direct sunlight and high-temperature stacking during freight.
• Shelf life: 24 months under standard storage.
• Classification: Non-hazardous general cargo.
• Avoid direct sunlight and high-temperature stacking during freight.
• Shelf life: 24 months under standard storage.
Main Derivative Downstream Raw Materials
As a highly versatile nucleotide precursor, our bulk Uridine is extensively utilized to manufacture the following downstream raw materials:
UMP
UDP
UTP
Idoxuridine
Floxuridine
2′-Deoxyuridine
5-Bromouridine
Disodium Uridine 5′-Monophosphate (Food-Grade)
UDP
UTP
Idoxuridine
Floxuridine
2′-Deoxyuridine
5-Bromouridine
Disodium Uridine 5′-Monophosphate (Food-Grade)
Request a Bulk Quote & Free Factory Sample
Flexible MOQ available for trial orders. Full SDS, batch COA, and chromatography data sheets provided with every commercial cargo.
FAQ
Q1: What grade of Uridine do mRNA synthesis laboratories usually purchase?
Most mRNA research institutions strictly select pharmaceutical grade Uridine with 99%+ HPLC purity and controlled endotoxin below 0.5 EU/mg. This ultra-low impurity profile prevents any negative impact on in-vitro transcription (IVT) reaction efficiency. We routinely provide endotoxin-free customized batches tailored for biotech laboratory clients.
Q2: Is your Uridine compliant with food additive regulations for infant formula UMP production?
Yes. Our fermentation-grade Uridine fully meets GB 1903.69-2024 food-grade precursor standards. We can consistently deliver food-class batches with zero heavy metal over-limits, perfectly supporting manufacturers in synthesizing high-purity disodium 5′-uridylate for infant nutrition fortifiers.
Q3: What is the difference between fermentation-produced Uridine and chemically synthesized Uridine?
Fermentation Uridine features significantly fewer heterocyclic impurities, uses a mild eco-friendly production process, and leaves lower toxic solvent residues. It offers vastly superior solubility stability and a higher matching success rate for demanding pharmaceutical and biological applications. Conversely, chemical synthesis Uridine is primarily restricted to low-demand industrial chemical experiments due to its higher impurity risks.
Q4: Can I get free Uridine samples before placing bulk orders?
Absolutely. We provide 10g–100g free test samples for initial evaluation; clients are only responsible for covering the international shipping cost. All verification samples come fully documented with an official COA, HPLC chromatogram, and MSDS/SDS sheets.
Q5: What is the standard delivery lead time for 25kg bulk Uridine orders?
Conventional stock items are shipped within 3–5 working days after deposit confirmation. Customized special purity specifications or large commercial batches typically require 7–12 production days. We offer door-to-door DHL/FedEx air freight as well as sea bulk container logistics for volume purchasers.
Q6: What documents can you provide for import customs clearance and factory audit?
We offer a comprehensive regulatory documentation package to support global customs clearance, including: Commercial Invoice, Packing List, Batch COA, HPLC Test Report, MSDS, Certificate of Origin (CO), third-party laboratory test reports, and formal ISO factory qualification files.
Q7: What storage problems will cause Uridine raw material degradation?
Long-term exposure to direct sunlight, high-humidity environments, or mixed storage with strong acids/oxidants will cause structural degradation, leading to product discoloration and a sharp decline in purity. Sealed, moisture-proof aluminum foil vacuum packaging is mandatory for maintaining long-term warehouse stock.
Q8: Do you support OEM private label packaging for Uridine resellers and distributors?
Yes, we provide full customizable label printing services for 1kg and 25kg packages. We can adjust outer box branding, batch codes, and chemical identifier information according to distributor criteria. For bulk contract orders over 500kg, no extra processing fees are applied.
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Complete Guide to Bulk Uridine Raw Material for Pharma, Biotech & Food Manufacturers
For global procurement managers of biotech labs, pharmaceutical factories, and food nutrition additive manufacturers, sourcing qualified bulk Uridine with stable purity and complete certification has become a core supply chain challenge in recent years. This expert guide breaks down Uridine grade classification, fermentation production advantages, key application scenarios, global supply standards, and bulk purchasing tips, helping industrial buyers select reliable factory suppliers and avoid common procurement pitfalls based on our 8-year export experience.
What Is Uridine & Core Chemical Properties Industrial Buyers Must Know
Uridine, chemically named 1-β-D-Ribofuranosyluracil, belongs to the pyrimidine nucleoside family, composed of a uracil base linked with β-D-ribofuranose via an N-glycosidic bond. Its physical index and chemical characteristics determine its performance in biological reaction environments. Detailed chemical profiles can be verified via the official NCBI PubChem Uridine Database.
| Chemical Property | Specification / Value | Procurement Significance |
|---|---|---|
| CAS Number | 58-96-8 | Standard global chemical identifier. |
| Molecular Formula | C9H12N2O6 (MW: 244.20) | Determines its highly water-soluble characteristic. |
| Melting Point Range | 163 – 167°C | Core indicator to distinguish genuine high-purity Uridine. |
| Specific Rotation | +8.4° | Critical quality inspection metric for purity verification. |
| Solubility & Appearance | Up to 50mg/mL in H2O (pH 4.0–6.0) | Must appear as a uniform white crystalline powder without clumping. |
Production Technology Alert: Fermentation vs. Chemical Synthesis
Unlike chemical synthesis which relies on high-temperature toxic chemical catalysis and leaves hard-to-remove single impurities, microbial bio-fermentation technology uses yeast strains to synthesize ribose and uracil under mild aqueous conditions. This significantly cuts residual organic solvent content. Most regulatory-compliant biotech and pharma buyers exclusively choose fermentation-derived Uridine.
Three Main Industrial Application Fields of Bulk Uridine Raw Material
1. Pharmaceutical Industry: Antiviral Intermediates & Metabolic Therapeutics
As the key starting material for synthesizing nucleoside antiviral drugs, Uridine is processed into Idoxuridine (herpes keratitis), Floxuridine (anti-tumor chemotherapy), and Bromodeoxyuridine. Beyond intermediates, compound oral medicines use Uridine combined with adenosine and inosine to improve myocardial and liver cell energy metabolism.
Strict Compliance Standard: USP/EP standard Uridine with endotoxin control below 0.5EU/mg is mandatory for injection-grade production. Heavy metal and arsenic limits must stay ≤ 5ppm to meet FDA and EU Pharmacopoeia (EDQM) import standards.
2. Biotech Research: mRNA Synthesis & Mammalian Cell Culture Supplement
In the fast-growing mRNA vaccine and gene therapy sectors, Uridine ranks among the four core nucleoside substrates alongside adenosine, guanosine, and cytidine. Labs require 99.8% high-purity low-endotoxin Uridine to guarantee high transcription efficiency during in-vitro mRNA synthesis. According to research published on PubMed Central (PMC), extracellular Uridine supplements pyrimidine nutrition to accelerate mammalian cell proliferation and reduce apoptosis rates in bioreactors.
3. Food Nutrition Field: Precursor of Infant Formula UMP Additive
Food-grade Uridine is the exclusive raw material used to produce disodium 5′-uridine monophosphate (UMP), a legal nutritional fortifier permitted under international infant food regulations that simulates natural breast milk nucleotide composition. For global compliance standards on food additives, procurement managers often refer to the Codex Alimentarius International Food Standards.
Uridine Grade Selection Guide for Industrial Buyers
Choosing the correct Uridine purity grade directly impacts downstream production yield and regulatory compliance. Three standardized grades cover all industrial demand scenarios:
GRADE 01
Industrial Biochemical Grade
Purity: ≥ 98% HPLC min.
Best For: Basic cell culture training and low-demand chemical synthesis. Unsuitable for pharma injection or infant food due to higher heavy metal thresholds (≤ 10ppm Pb).
GRADE 02
USP/EP Pharmaceutical Grade
Purity: 99.0% – 101.0% HPLC.
Best For: Antiviral intermediate factories, mRNA research labs, and oral medicine manufacturers. Strictly controlled single impurities aligned with USP standards.
GRADE 03
Research Calibration Standard
Purity: ≥ 99.8% HPLC.
Best For: Analytical laboratories conducting HPLC/NMR quantitative testing. Double calibrated purity, ultra-low moisture, sold in 1g–50g packaging.
* Procurement Advice: Always verify the COA for HPLC chromatogram attachments, ignition residue, and related substance impurity data before confirming batch shipments.
Bulk Uridine Global Procurement & Storage Logistics Best Practices
Packaging & Shipping Standards
- Tiered Packaging: 1kg vacuum aluminum foil bags for labs; 25kg fiber drums lined with double PE plastic bags for full bulk containers.
- Non-Hazardous Status: Classed as non-hazardous general cargo, reducing international transport and customs clearance costs.
- Freight Modes: Air express via DHL/FedEx for <50kg; Sea FCL/LCL shipping is highly economical for bulk volumes above 500kg.
Long-Term Storage Rules
- Climate Control: Keep in cool, dry warehouses under 25°C. Pharmaceutical grades require 2–8°C refrigeration for an extended shelf life of up to 24 months.
- Chemical Segregation: Never mix with strong acids, oxidants, or volatile organic chemicals to avoid irreversible powder discoloration and purity drop.
How To Identify Reliable Uridine Factory Suppliers & Avoid Risks
Many trading companies resell low-quality chemical synthetic Uridine without production qualification. Industrial buyers can filter out high-quality manufacturing partners using these 4 Core Verification Standards:
1
Direct Manufacturing Workshop: Must possess an independent fermentation production line (not third-party repackaged goods) and provide ISO quality system certifications.
2
Complete Batch Documentation: Ready access to full batch test documents including verified COA, HPLC chromatograms, MSDS, and independent third-party lab testing reports.
3
Scalable Capacity & Customization: Supports customized purity, endotoxin limits, and specific packaging requirements, with a stable monthly production capacity exceeding 10 tons.
4
Pre-Production Sampling: Offers free pre-production test samples with complete validation records before signing large bulk commercial procurement contracts.
