Book Appointment Now
GDP·Na₂CAS：7415-69-2
Guanosine 5′-diphosphate disodium salt (GDP Na2) is high-purity water-soluble nucleotide raw material with CAS number 7415-69-2. Our factory produces this white crystalline powder via biological fermentation & enzyme catalysis, low heavy metal, strict HPLC quality control. It acts as core substrate for GTPase, G-protein signal research, cell culture medium additive and GTP synthesis precursor. We support small lab trial orders and bulk industrial 25kg drum wholesale, offer free COA, MSDS and customized packaging for global biotech, pharmaceutical and research institute buyers.
Global Supply Capabilities & B2B Commercial Advantages
🎯
Tiered Purity Standard
Available in three tailored HPLC purity grades: 90%, 95%, and 98% standard reference grade to perfectly match your budget and application.
Available in three tailored HPLC purity grades: 90%, 95%, and 98% standard reference grade to perfectly match your budget and application.
🧪
Premium Physical Properties
Features ultra-high water solubility and a highly stable crystalline powder state with extremely low GMP/GTP impurity limits.
Features ultra-high water solubility and a highly stable crystalline powder state with extremely low GMP/GTP impurity limits.
🏭
1,000kg Monthly Bulk Output
Large-scale factory operations guarantee a stable monthly output of 1000kg with express shipping pathways to the US, EU, and Southeast Asia.
Large-scale factory operations guarantee a stable monthly output of 1000kg with express shipping pathways to the US, EU, and Southeast Asia.
📋
100% Traceable Certificates
Shipped with an audit-ready file package: COA, HPLC test reports, MSDS, and heavy metal inspection sheets for seamless customs clearance.
Shipped with an audit-ready file package: COA, HPLC test reports, MSDS, and heavy metal inspection sheets for seamless customs clearance.
📦
Flexible Pack Configurations
Supports 100g/1kg aluminum foil vacuum bags for trials and 25kg industrial fiber drums equipped with protective PE inner liners.
Supports 100g/1kg aluminum foil vacuum bags for trials and 25kg industrial fiber drums equipped with protective PE inner liners.
🤝
Risk-Free Sourcing Solutions
Enjoy exclusive B2B services: free-of-charge testing samples, full third-party testing alignment, and deep technical data guidance.
Enjoy exclusive B2B services: free-of-charge testing samples, full third-party testing alignment, and deep technical data guidance.
🚀 Ready to streamline your nucleotide supply chain and secure wholesale pricing?
Apply For Your Free Sample Kit
Product Specs
Guanosine 5′-Diphosphate Disodium Salt (GDP Na2) Bulk Supply & Technical Specifications
Basic Chemical Identity Table (Schema Friendly)
| Item | Standard Parameter |
|---|---|
| Full Name | Guanosine 5′-Diphosphate Disodium Salt |
| Short Alias | GDP Na2, 5′-GDP Disodium Salt |
| CAS No. | 7415-69-2 |
| Molecular Formula | C₁₀H₁₃N₅Na₂O₁₁P₂ |
| Molecular Weight | 487.16 |
| Appearance | White or off-white crystalline powder |
| Solubility | Freely soluble in water, insoluble in ethanol, acetone, ether |
| 1% Aqueous pH Value | 7.0–8.0 |
| UV Characteristic (pH7 Buffer) | λmax=256nm, ε256=13.7 mM⁻¹·cm⁻¹ |
| A250/A260 Ratio | 0.96±0.05 |
| A280/A260 Ratio | 0.67±0.03 |
Quality Control Index & Purity Classification
1. HPLC Purity Grades for Diverse Applications
GRADE A
Lab Reagent Grade (≥90% HPLC)
Optimized for general cell culture applications.
Lab Reagent Grade (≥90% HPLC)
Optimized for general cell culture applications.
GRADE AA
Biochemical Research Grade (≥95% HPLC)
Perfect for sensitive GTPase & GPCR screening assays.
Biochemical Research Grade (≥95% HPLC)
Perfect for sensitive GTPase & GPCR screening assays.
PREMIUM GRADE
Chromatography Standard Grade (≥98% HPLC)
Strictly targeted as a pharmaceutical intermediate & HPLC reference standard.
Chromatography Standard Grade (≥98% HPLC)
Strictly targeted as a pharmaceutical intermediate & HPLC reference standard.
2. Strict Impurity Limit Control
• Guanosine monophosphate (GMP): ≤2.0%
• Guanosine triphosphate (GTP): ≤1.0%
• Loss on drying: ≤5.0%
• Heavy metals (Pb, As, Cd, Hg): ≤10 ppm
• Residual solvent: Undetected (Fully Compliant)
Physical Stability & Storage Instructions
- Solid Powder Storage: Must be kept in a sealed, dry container at -20°C for a 12-month shelf life. Storage at 2–8°C is valid for only 1 month after opening.
- Aqueous Solution Sensitivity: Highly unstable at room temperature; significant hydrolysis occurs within 24 hours. Always prepare fresh solutions immediately before each experiment.
- Environmental Triggers: Strictly avoid contact with strong acids, high temperatures, direct sunlight, and humid air.
Advanced Production Routes & Factory Differentiation
Our factory operates two distinct, highly mature production lines to fulfill diverse client requirements and eliminate middleman trading markups:
1. Microbial Fermentation Route
Designed for mass industrial bulk orders. Utilizes guanosine fermented by Corynebacterium, followed by two-step phosphate esterification and sodium salt recrystallization. Offers an exceptionally low production cost for 5kg–25kg bulk purchases.
Designed for mass industrial bulk orders. Utilizes guanosine fermented by Corynebacterium, followed by two-step phosphate esterification and sodium salt recrystallization. Offers an exceptionally low production cost for 5kg–25kg bulk purchases.
2. Enzymatic Catalysis Route
Targeted for laboratory standard substance buyers requiring high purity. Features highly purified GTP raw material hydrolysis via nucleotide diphosphatase, ensuring minimal heterologous impurities.
Targeted for laboratory standard substance buyers requiring high purity. Features highly purified GTP raw material hydrolysis via nucleotide diphosphatase, ensuring minimal heterologous impurities.
Global Packaging & Logistics Plan
📦 Small Trial Packages
Available in 100mg, 500mg, and 1kg sizes. Packed in specialized vacuum aluminum foil bags with robust moisture-proof sealing.
Available in 100mg, 500mg, and 1kg sizes. Packed in specialized vacuum aluminum foil bags with robust moisture-proof sealing.
🏭 Industrial Bulk Packaging
Standardized 25kg fiber drums equipped with double PE inner bags and industrial desiccant to preserve molecular stability.
Standardized 25kg fiber drums equipped with double PE inner bags and industrial desiccant to preserve molecular stability.
✈️ Reliable Global Shipping
Fast air express for critical laboratory small samples; professional ocean freight for bulk industrial cargo. Full door-to-door delivery available.
Fast air express for critical laboratory small samples; professional ocean freight for bulk industrial cargo. Full door-to-door delivery available.
B2B Exclusive Procurement Services
🎁 Free R&D Samples: 5–20g testing samples available for qualified biotech manufacturers & research institutions.
📄 Complete Technical Documentation: Every shipment includes comprehensive MSDS, COA, HPLC chromatograms, and UV spectrum reports.
🔬 Expert Technical Support: Direct access to our professional biochemists for experimental parameter adjustments.
🛡️ Third-Party Verification: We proudly accept independent pre-shipment inspections by SGS or Intertek.
FAQ
🔹 Chemical Properties & Material Comparison
Q1
What is the difference between GDP disodium salt, GDP free acid and GDP monosodium salt?
GDP disodium salt (CAS 7415-69-2) owns two sodium ions, providing the best water solubility and a neutral pH ideal for cell experiments, making it the most widely purchased form globally. In contrast, GDP free acid has poor water solubility and is rarely used commercially, while GDP monosodium salt carries only one sodium ion, leading to an unstable aqueous solution and a highly limited application range.
Q2
How to distinguish fermentation-grade GMP from low-quality RNA hydrolysis GMP?
Fermentation disodium 5′-guanylate features a higher purity of ≥99%, fewer impurity nucleotides, and a stable batch-to-batch taste profile. Cheap RNA hydrolysis products contain mixed nucleotide impurities that easily produce a bitter aftertaste in finished foods. Our detailed COA reports include specific UV absorbance ratio testing data to guarantee 100% pure fermentation-grade raw materials.
🔹 Applications & Downstream Research
Q3
Can GDP Na2 directly replace GTP in RNA synthesis experiments?
It cannot replace GTP directly. However, pyruvate kinase can catalyze GDP phosphorylation to successfully generate GTP. Therefore, GDP disodium salt is widely utilized as a low-cost circulating raw material for advanced in vitro transcription systems.
Q4
What application scenarios require ≥98% high purity GDP disodium salt?
Our 98% standard grade is strictly required for HPLC quantitative reference substances, pharmaceutical intermediate synthesis, precise GTPase enzyme kinetic testing, and cellular model research focused on inflammatory diseases.
Q5
What downstream pharmaceutical research uses GDP Na2 as a core raw material?
It is heavily applied in GPCR target drug screening, neurodegenerative disease mechanism investigation, and inflammation-related iron metabolism regulation studies.
🔹 Stability, Storage & Handling Tips
Q6
How to prevent GDP disodium salt powder from caking during storage?
This product exhibits strong hygroscopicity. Immediately after opening the package, seal it quickly with vacuum tape, store it in a dry refrigerator with an active desiccant, and avoid repeated exposure to humid air.
Q7
Will aqueous GDP disodium solution degrade overnight at 4℃?
Yes. Slow hydrolysis still takes place under refrigeration. To guarantee absolute test accuracy, it is highly recommended to prepare your working solution within 12 hours prior to the experiment.
🔹 B2B Supply Chain & Logistics
Q8
What’s your minimum order quantity for factory wholesale?
Our standard factory wholesale MOQ starts at 100g for initial laboratory trials. For formal bulk industrial orders, we fully support a 5kg to 1000kg monthly supply with tiered unit price discounts.
Q9
Can you customize special packaging or labels for private laboratory brands?
Absolutely. We provide comprehensive OEM support including customized printed labels and independent vacuum packaging for qualified research institutes and regional reagent distributors with bulk order commitments.
Q10
Is GDP Na2 hazardous for transit, and what documents are provided?
The product is classified as non-dangerous chemical goods with no UN hazard classification, allowing for standard air and sea freight under simple moisture-proof treatment. For smooth customs clearance, we supply a complete documentation package for EU, US, and Australia customs: Commercial Invoice, Packing List, MSDS, COA, and Factory Production Qualification Certificates.
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Complete Guide to Guanosine 5′-Diphosphate Disodium Salt GDP Na2 (CAS 7415-69-2) for Biotech & Pharmaceutical Buyers
Global biotech laboratories, pharmaceutical R&D institutions, and nucleotide raw material manufacturers constantly seek reliable, high-purity guanosine 5′-diphosphate disodium salt suppliers. GDP Na2 (CAS 7415-69-2) is a core purine nucleoside diphosphate that dominates cell signaling pathway research and industrial GTP synthesis. This comprehensive B2B sourcing guide covers critical chemical properties, advanced production tech, tiered quality standards, and bulk procurement workflows.
1. Basic Chemical & Physical Properties of Guanosine 5′-Diphosphate Disodium Salt
Guanosine 5′-diphosphate disodium salt carries two sodium cations to neutralize diphosphate groups, greatly boosting water solubility compared with free GDP acid.
Formula & MW
C₁₀H₁₃N₅Na₂O₁₁P₂
Molecular Weight: 487.16
C₁₀H₁₃N₅Na₂O₁₁P₂
Molecular Weight: 487.16
Appearance & pH
White Crystal Powder
Aqueous pH: 7.0–8.0 (Neutral)
White Crystal Powder
Aqueous pH: 7.0–8.0 (Neutral)
UV Characteristics
λmax = 256nm
Strictly controlled A250/A260 ratios
λmax = 256nm
Strictly controlled A250/A260 ratios
⚠️ Stability Alert for Lab Operators:
Solid GDP disodium salt sealed under -20°C dry dark environments maintains stable purity for 12 months. However, once dissolved in aqueous solution, pyrophosphate bonds gradually break down at room temperature, producing GMP and inorganic phosphate. Always prepare fresh solutions before each experiment to avoid data deviation.
Solid GDP disodium salt sealed under -20°C dry dark environments maintains stable purity for 12 months. However, once dissolved in aqueous solution, pyrophosphate bonds gradually break down at room temperature, producing GMP and inorganic phosphate. Always prepare fresh solutions before each experiment to avoid data deviation.
2. Three Purity Grades of GDP Na2 and Corresponding B2B Buyer Groups
Our factory divides finished products into three standard grades based on HPLC testing data, helping purchasing managers avoid over-spending or insufficient purity:
2.1 90% HPLC General Biochemical Grade
Controls main impurities under 3%. Suitable for basic cell proliferation culture, microbial fermentation additives, and university laboratory teaching. Chosen mostly by low-budget retail reagent distributors who require stable monthly supply capacities. Heavy metal inspection still follows pharmaceutical standards to guarantee biosafety.
2.2 95% HPLC Research Special Grade
The most popular specification among global biotech research labs. Low GTP and GMP residual limits guarantee accurate GTPase activity testing, GPCR ligand screening, and Ras protein signaling pathway study. Most European and American academic research institutes maintain regular repeat orders of 1–5kg for this grade.
2.3 98% HPLC Chromatography Standard Grade
High-purity 98% GDP Na2 targets pharmaceutical intermediate synthesis factories and HPLC standard substance manufacturers. Strict impurity filtering eliminates interfering substances during drug compounding and chromatographic qualitative/quantitative analysis. It adopts an enzymatic hydrolysis craft to reduce heterologous protein residues, making it ideal for clinical drug development projects.
3. Main Industrial & Laboratory Applications of Guanosine 5′-Diphosphate Disodium Salt
GDP disodium salt occupies an irreplaceable position across molecular biology, pharmaceutical R&D, cell engineering, and fermentation manufacturing industries:
3.1 Biochemical Enzyme Assay & GPCR Target Research
As the natural ligand of G-protein α subunits, GDP Na2 maintains the G-protein inactive state, acting as the core control substrate for GTPase enzyme kinetic testing. Used to evaluate activation efficiency for neurological and inflammatory disease therapeutics.
As the natural ligand of G-protein α subunits, GDP Na2 maintains the G-protein inactive state, acting as the core control substrate for GTPase enzyme kinetic testing. Used to evaluate activation efficiency for neurological and inflammatory disease therapeutics.
3.2 In Vitro Transcription & Nucleotide Circulation Systems
Pyruvate kinase converts GDP into GTP continuously, cutting raw material costs for large-scale RNA synthesis. Many mRNA vaccine R&D laboratories bulk purchase GDP disodium salt to build low-cost cyclic nucleotide supply systems instead of buying expensive direct GTP raw materials.
Pyruvate kinase converts GDP into GTP continuously, cutting raw material costs for large-scale RNA synthesis. Many mRNA vaccine R&D laboratories bulk purchase GDP disodium salt to build low-cost cyclic nucleotide supply systems instead of buying expensive direct GTP raw materials.
3.3 High-End Mammalian Cell Culture Medium Additives
Stem cell and primary neuron cultures require balanced intracellular guanine nucleotide concentrations. Adding proper GDP Na2 stabilizes cell signal homeostasis, improving cell viability and differentiation consistency in serum-free culture formulas.
Stem cell and primary neuron cultures require balanced intracellular guanine nucleotide concentrations. Adding proper GDP Na2 stabilizes cell signal homeostasis, improving cell viability and differentiation consistency in serum-free culture formulas.
3.4 Industrial Fermentation Auxiliaries for Nucleotide Production
Corynebacterium fermentation factories add GDP disodium salt to increase intracellular GTP accumulation, raising the final yield of food-grade and pharmaceutical-grade guanosine derivatives for continuous mass production.
Corynebacterium fermentation factories add GDP disodium salt to increase intracellular GTP accumulation, raising the final yield of food-grade and pharmaceutical-grade guanosine derivatives for continuous mass production.
4. Two Mature Production Processes for Factory Bulk GDP Disodium Salt
Our factory operates two independent production lines to meet mass bulk orders and high-purity small orders separately, differentiating our professional facility from simple trading intermediaries:
⛓️ Fermentation Synthesis Route (Mass Bulk)
Microbes first produce guanosine via deep fermentation, followed by chemical two-step phosphorylation and sodium salt recrystallization. This process controls production costs effectively for industrial downstream factories with monthly ton-level demand (5kg–25kg bulk drums).
Microbes first produce guanosine via deep fermentation, followed by chemical two-step phosphorylation and sodium salt recrystallization. This process controls production costs effectively for industrial downstream factories with monthly ton-level demand (5kg–25kg bulk drums).
🧬 Enzymatic Catalytic Route (High Purity Grade)
Purified GTP raw material undergoes directional hydrolysis via fixed nucleotide diphosphatase, removing redundant phosphate groups precisely. The finished product contains nearly zero heterologous impurities, fully complying with EU and US FDA pharmaceutical access standards.
Purified GTP raw material undergoes directional hydrolysis via fixed nucleotide diphosphatase, removing redundant phosphate groups precisely. The finished product contains nearly zero heterologous impurities, fully complying with EU and US FDA pharmaceutical access standards.
5. Standard Storage, Packaging & Global Shipping Guide for B2B Buyers
Because of its strong hygroscopicity, professional packaging and quick transport handling are mandatory to maintain product activity:
- 📦Packaging Options: Lab trial samples use 100g–1kg vacuum foil bags with moisture barrier layers. Industrial bulk goods adopt 25kg fiber drums lined with double PE plastic bags and desiccant packs. Custom private labeling is supported for distributors.
- ✈️Global Shipping: Classified as non-dangerous goods. Small lab samples choose DHL/FedEx air express for door-to-door delivery within 5–7 working days. Mass bulk cargo is arranged via ocean freight with full temperature control considerations.
- 📄Customs Clearance: Every shipment arrives with complete documentation, including MSDS, COA, HPLC chromatograms, and factory qualification certificates to avoid port or customs detention.
6. Key Factors for B2B Buyers to Select Reliable GDP Na2 Factory Suppliers
🛡️ Quality Assurance & Factory Verification Standards
- Traceable Chromatograms: Confirm independent production workshops and complete batch HPLC testing records. Intermediary traders cannot provide real-time chromatogram reports for every batch.
- Full Technical Support: Our factory deploys specialized biochemists to provide experiment parameter guidance and impurity data analysis for clients’ projects.
- Risk-Free Trials: We offer free 5g–20g testing samples for qualified biotech and pharmaceutical enterprises, and proudly support independent SGS or Intertek third-party testing before shipment production.
Get Wholesale Quotation & Free Samples Today
Selecting matching purity grades, mastering storage stability rules, and cooperating with certified production factories directly reduces your procurement costs and clinical experiment failure risks.
