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UDP·Na₂ CAS：27821-45-0
Factory bulk supply high purity Uridine 5′-Diphosphate Disodium Salt UDP Na₂ CAS 27821-45-0. HPLC 98% 99% nucleotide raw material for glycosyltransferase research, pharmaceutical intermediate and cell culture assay kits. Stable stock, COA & SDS available.
Product Specs
Product Specifications & Chemical Data
| Item | Full Parameter Data |
|---|---|
| IUPAC Name | Disodium [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate |
| Molecular Formula | C9H12N2Na2O12P2 (Anhydrous) |
| Molecular Weight | 448.12 g/mol |
| SMILES Code | O=c1[nH]ccc(=O)n1C1OC(COP(=O)([O-])OP(=O)(O)[O-])C(O)C1O.[Na+].[Na+] |
| InChI Key | YQHKXOXMGBLJRM-VJYXFCLXSA-L |
| Product Form | Hydrated crystalline powder (controlled moisture content) |
Physical & Stability Properties
- UV Absorption Feature (pH 2 aqueous solution): Max absorbance 262 nm | A250/A260 = 0.75±0.05 | A280/A260 = 0.38±0.05
- 1% Aqueous Solution pH Value: 7.0 to 9.0 (Weak alkaline)
- Degradation Risk & Stability: Pyrophosphate bond hydrolyzes under room temperature humid conditions. The aqueous solution remains stable for only 72 hours at 4°C.
- Heavy Metal Control Standard: Lead (Pb), Cadmium (Cd), Arsenic (As), Mercury (Hg) Total ≤ 10 ppm
- Nucleotide Impurity Limit: UMP, UTP, uridine single impurity ≤ 0.5%; Total related substances ≤ 1.0% (for 99% Pharma Grade)
- Microbial Index: Total aerobic bacteria < 100 CFU/g; E.coli, mold, and yeast not detected.
Why Choose Us? Factory Supply Advantages
Mass Production Capacity
Independent nucleotide synthesis workshop with a full chemical synthesis line. Stable monthly output up to 120kg without outsourcing.
Complete Quality Reports
Third-party HPLC testing for every batch. Free COA, SDS, and HPLC chromatogram reports are dispatched directly with the cargo.
Custom Purity Service
Flexible customization options: adjust moisture and impurity content precisely for biotech labs or pharmaceutical intermediate production lines.
Flexible Global Shipping
Supported trade terms: FOB Shanghai, CFR, CIF global ports. Accepted bulk payment methods: T/T, L/C, Western Union.
Technical Support
Full after-sales tech support providing storage guidance, solution preparation protocols, and application technical documents for labs and manufacturers.
24-Month Shelf Life
Long shelf life guaranteed. Unopened product sealed and stored at minus 20 centigrade (-20°C) remains valid for 24 months.
Safety Handling Standards (GHS SDS Core Data)
Hazard Category: Skin irritation Category 2, eye irritation Category 2, single exposure respiratory irritation Category 3.
Mandatory Operation Gear: Nitrile gloves, dust mask, splash-proof safety goggles, must be handled within a ventilated fume hood.
Waste Disposal: Solid waste must be classified as biochemical hazardous waste. Dilute and neutralize aqueous waste thoroughly before drainage.
⚠️ Toxicity Note: No acute oral toxicity, only local mucosal irritation. NOT for direct human oral administration.
FAQ
Frequently Asked Questions (FAQ) – Uridine 5′-Diphosphate Disodium Salt
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Uridine 5′-Diphosphate Disodium Salt (UDP Na₂) Complete Guide for Biotech & Pharmaceutical Bulk Buyers
This comprehensive guide delivers essential chemical insights, industrial applications, compliance standards, and factory supply capabilities for procurement managers looking to source high-purity UDP disodium raw materials.
1. Core Definition & Chemical Structure of UDP Disodium (CAS 27821-45-0)
Uridine 5′-Diphosphate Disodium Salt, widely shortened as UDP Na₂ or 5′-UDP 2Na, is a critical pyrimidine nucleotide raw material favored by global biotech laboratories, glycosylation research institutions, and pharmaceutical intermediate manufacturers. Registered under the official CAS Registry Number 27821-45-0, this hydrated crystalline compound features a uridine nucleoside backbone connected with a pyrophosphate disodium group, forming a highly stable, water-soluble powder ideal for in vitro enzymatic testing and industrial drug synthesis.
Distinct from UDP free acid and UDP trisodium variants, the disodium salt delivers a balanced, neutral-to-weak alkaline aqueous pH between 7.0 and 9.0. This optimal pH environment eliminates acidic damage to sensitive glycosyltransferase enzymes during experimental incubation. Its molecular formula is C9H12N2Na2O12P2, yielding a molecular weight of 448.12 g/mol for the anhydrous form. Commercial bulk stock strictly maintains controlled hydrate moisture to balance stability and solubility without accelerated hydrolysis risks. Detailed bio-chemical structural data can also be referenced on the NCBI PubChem Database.
⚠️ Vital Inspection Note for Buyers: Qualified UDP disodium presents a uniform white to off-white fine crystal powder without yellow discoloration or agglomeration. High hygroscopicity is a core chemical characteristic—exposure to ambient air absorbs moisture within minutes, breaking the fragile pyrophosphate chemical bond and reducing effective purity significantly. Standard UV spectrum testing at a 262 nm maximum absorbance serves as quick identity verification before formal HPLC purity detection.
2. Main Industrial & Laboratory Application Scenarios for Bulk UDP Na₂ Raw Material
Global B2B nucleotide buyers source UDP disodium for four high-demand core verticals, each with unique purity grade selection criteria matching production or research requirements:
2.1 Glycosyltransferase Enzyme Assay & Glycobiology Research
UDP disodium functions as the mandatory sugar nucleotide precursor to manufacture UDP-glucose, UDP-galactose, and UDP-glucuronic acid inside cell-free reaction systems. Academic labs and biotech CRO facilities purchase kilogram-level 98% HPLC grade UDP Na₂ to explore glycoprotein, glycolipid, and proteoglycan formation mechanisms, supporting studies on cell adhesion, immune response, and inflammatory pathways. Compared with low-purity lab reagents, factory bulk UDP removes residual RNase/DNase contamination to avoid experimental sample degradation, cutting repeated testing costs for long-term research projects.
2.2 P2Y6 Purinergic Receptor Pharmacology Research
As a highly selective endogenous agonist for P2Y6 cell membrane receptors, UDP disodium is irreplaceable for preclinical drug screening targeting inflammation, microglial activation, and tissue repair treatments. Pharmaceutical R&D teams utilize pharmaceutical grade ≥99% UDP Na₂ to build in vitro cell models, testing antagonist compound efficacy and calculating EC50 values for new therapeutic molecule development. Strict heavy metal limits below 10 ppm eliminate background interference during high-sensitivity receptor binding tests.
2.3 Pharmaceutical Nucleotide Intermediate Manufacturing
Active Pharmaceutical Ingredient (API) and ophthalmic drug factories rely on high-purity UDP disodium as the starting material for synthesizing uridine-based therapeutic agents, including eye drop formulations targeting ocular circulation disorders. Mass production lines demand consistent low-impurity profiles: single related nucleotide contaminants (UMP, UTP, free uridine) are capped under 0.3% to prevent unwanted byproducts during multi-step chemical synthesis. Factory-direct bulk supply eliminates middleman markup, supporting stable monthly production cycles.
2.4 In Vitro Diagnostic Kit & Cell Culture Additive
Diagnostic reagent manufacturers integrate UDP disodium into enzyme activity detection kits for glycosidase and transferase quantification. Biotech cell culture labs add diluted UDP Na₂ solution into specialized culture media to regulate cellular nucleotide metabolism, improving differentiation efficiency for regenerative medicine and tissue engineering research. Trial-sized small packaging (100mg to 5g) perfectly suits diagnostic startup companies conducting prototype kit validation before large-scale mass procurement.
3. Critical Quality Index Standards B2B Buyers Must Check Before Bulk Purchase
Professional procurement managers from research institutes and drug factories prioritize six core testing indicators to validate UDP Na₂ batch quality, avoiding performance loss in downstream production or research workflows:
- HPLC Purity Grade (Three-Tiered Standards):
• 96% Academic Lab Grade — For basic teaching and general assays.
• 98% Biotech Research Grade — For advanced glycobiology testing and CRO labs.
• 99% Pharmaceutical Intermediate Grade — For strict drug synthesis and preclinical pharmacology.
- Moisture Content Control: Hydrated commercial goods maintain moisture below 10%, while anhydrous customized orders limit water under 1.0% for long-term tropical warehouse storage.
- Single Impurity Restriction: Top-tier factory batches restrict individual nucleotide impurities (UMP, UTP, uridine) under 0.5%, and total unknown related substances below 1.0%.
- Heavy Metal Toxic Elements: Combined lead, arsenic, cadmium, and mercury content must not exceed 10 ppm, meeting international biotech raw material regulations.
- Microbial Limit Inspection: Total aerobic bacteria <100 CFU/g with zero E.coli, mold, or yeast detected, which is mandatory for raw materials contacting live cell cultures.
- Aqueous Solubility Verification: Confirms complete dissolution in deionized water without insoluble sediment, proving no degraded low-molecular byproducts are mixed within the finished powder.
*Note: All qualified bulk shipments attach full official documentation packages including COA, SDS (compliant with OSHA GHS standards), HPLC chromatogram scans, heavy metal test reports, and microbial inspection certificates.
4. Proper Storage, Packaging & Transportation Rules to Protect UDP Disodium Purity
UDP disodium’s hygroscopic and light-sensitive chemical properties necessitate strict logistics and storage rules all bulk buyers need to implement immediately after cargo arrival:
| Storage Type | Mandatory Condition & Shelf Life |
|---|---|
| Long-term Bulk Inventory | Unopened vacuum aluminum foil bags at -20°C constant temperature. Fully isolated from humid air and direct sunlight. Valid for 24 months. |
| Opened Raw Material | Transfer remaining powder into airtight moisture-proof containers, store at 2–8°C, and consume completely within 3 months to prevent pyrophosphate hydrolysis. |
| Aqueous Working Solution | Lacks long-term stability. Even under refrigeration at 4°C, prepared liquid solutions only retain full activity for a maximum of 72 hours. Prepare fresh before each experiment. |
Our factory standard packaging balances cargo safety and flexible order volume. Small trial laboratory orders adopt single-use vacuum foil packs ranging from 100mg up to 5 grams. Industrial mass bulk shipments utilize 1kg inner double PE-lined aluminum foil bags, sealed and packed inside 25kg thick fiber drums with moisture-barrier top caps to resist temperature fluctuations during cross-ocean shipping. Global transportation uses reliable cold chain logistics for large bulk orders to maintain stable low-humidity environments across long sea freight transit times.
5. Factory Direct Supply Advantages for Global UDP Na₂ Bulk Purchasers
Sourcing UDP disodium directly from professional nucleotide synthesis factories delivers measurable cost and technical benefits compared to purchasing through chemical reagent distributors:
Competitive Pricing
Independent full synthesis production lines remove intermediate markup, offering competitive unit pricing for kilogram and metric ton bulk orders, with flexible MOQ.
Independent full synthesis production lines remove intermediate markup, offering competitive unit pricing for kilogram and metric ton bulk orders, with flexible MOQ.
One-Stop Tailoring
Our factory technical team provides custom purity adjustment, moisture content modification, tailored packaging label printing, and step-by-step preparation guidance.
Our factory technical team provides custom purity adjustment, moisture content modification, tailored packaging label printing, and step-by-step preparation guidance.
Consistent Capacity
Eliminate unexpected stock shortage risks with large-scale monthly output. We support stable, long-term annual framework supply contracts for biotech CROs.
Eliminate unexpected stock shortage risks with large-scale monthly output. We support stable, long-term annual framework supply contracts for biotech CROs.
Seamless Logistics
Complete international shipping document sets streamline customs clearance across Europe, North America, and Asian markets in compliance with global trade standards.
Complete international shipping document sets streamline customs clearance across Europe, North America, and Asian markets in compliance with global trade standards.
