Book Appointment Now
CTP-Na₂ CAS：36051-68-0
We supply high-quality cytidine 5′-triphosphate disodium salt, also known as CTP disodium or 5′-CTP 2Na, a core pyrimidine nucleoside triphosphate nucleotide raw material. Our factory adopts enzyme catalytic synthesis to deliver low impurity, RNase/DNase-free powder for pharmaceutical injection intermediates, in vitro transcription mRNA production, biochemical lab research and industrial fermentation. Multiple purity grades and bulk packaging available with full test documents for global biotech, pharma and lab distributors.
Product Specs
High-purity Cytidine 5′-triphosphate disodium salt (CTP-Na2) manufactured via advanced bio-enzymatic conversion. Available in Pharmaceutical, Molecular Biology, and Industrial Fermentation grades with strict QC standards.
2.1 Basic Chemical Identity
| Standard Parameter | Value / Description |
|---|---|
| Full Chemical Name | Cytidine 5′-triphosphate disodium salt |
| Synonyms | CTP disodium, 5′-CTP disodium salt, Cytidine triphosphate disodium |
| CAS Number | 36051-68-0 (anhydrous); Hydrate CAS: 81012-87-5 |
| EC Number | 252-849-3 |
| MDL Number | MFCD00078193 |
| Molecular Formula | C9H14N3Na2O14P3 |
| Molecular Weight | 527.12 (anhydrous) |
| UV Characteristic Peak | λmax 271nm (pH 8.2) |
2.2 Physicochemical Properties
- Appearance: White crystalline hygroscopic powder
- Solubility: Freely soluble in purified water; insoluble in ethanol, acetone, ether
- 1% Aqueous pH Value: 7.0–8.5
- Thermal Stability: Degrades under high temperature; aqueous solution hydrolyzes rapidly above 40℃
- Hygroscopicity: Strong, must be stored in sealed moisture-proof containers
2.3 Grade Quality Standards (B2B Core Demands)
1. Pharmaceutical Injection Grade (Top Tier)
- HPLC Assay: ≥98.0%
- Impurities: Single related impurity ≤0.5%, total impurities ≤2.0%
- Water Content: ≤8.0%
- Heavy Metals (Pb, As, Cd, Hg): ≤10ppm
- Bacterial Endotoxin: <0.1 EU/mg
- Microbial Control: Sterile, no microbial contamination, nuclease negative
2. Molecular Biology Lab Grade
- HPLC Assay: ≥98%
- Nuclease Test: Nuclease-free test passed
- Safety: Heavy metals ≤5ppm, low endotoxin optimized for cell experiments
3. Industrial Fermentation Grade
- HPLC Assay: ≥95%
- Application: Qualified and optimized for enzyme catalytic substrate production
2.4 Production Process Advantages (E-E-A-T Signal)
Advanced Bio-Enzymatic Conversion Technology
Our advanced production utilizes bio-enzymatic conversion technology rather than traditional chemical synthesis. The raw material CMP reacts with ATP under yeast kinase catalysis within a constant temperature, neutral buffer environment. Following protein removal via ultrafiltration, ion exchange desalination, low-temperature ethanol crystallization, and vacuum freeze drying, the finished high-purity powder is obtained.
Why Choose Our Process? Guarantees a single stereoisomer • Minimal by-products • Zero toxic organic solvent residue • Fully compliant with strict pharmaceutical raw material export standards.
2.5 Packaging, Storage & Transportation
| Category | Specifications & Guidelines |
|---|---|
| Packaging Options | • Lab Trial Package: 100mg, 500mg, 1g vacuum aluminum foil bags • Bulk Commercial/Pharma: 1kg inner vacuum foil bag; 25kg fiber drum with double PE inner liners • Customized packaging available for long-term contract clients. |
| Storage Rules | • Long-Term Storage: -20℃ sealed, light-proof, and moisture-isolated. Shelf life of 36 months when unopened. • Short-Term Lab Use: 2–8℃ sealed; best used within 30 days after opening. • Aqueous Solution: Prepare fresh immediately before use; strictly avoid repeated freeze-thaw cycles. |
| Transportation | Classified as non-dangerous biochemical goods; eligible for normal land, sea, or air shipping. Avoid direct sunlight and high-temperature exposure. High-purity lab grades can be shipped via cold chain upon request. |
2.6 Safety & SDS Core Information
- Hazard Profile: Non-flammable, non-corrosive, low skin irritation.
- Handling Requirements: Wear disposable gloves and a dust mask to prevent powder inhalation during operation.
- Emergency Measures: In case of contact, flush skin or eyes immediately with plenty of clean water. If accidentally ingested, drink sufficient water and seek medical attention if necessary.
- Waste Disposal: Dissolve in water and process appropriately as biochemical waste liquid.
FAQ
Frequently Asked Questions (FAQ) & Buyer Guide
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Cytidine 5′-Triphosphate Disodium Salt:
Complete Guide for Biotech, Pharma, and Industrial Bulk Buyers
A premium-grade nucleotide intermediate manufactured via stable bio-enzymatic conversion. Fully compliant with international regulatory and pharmaceutical standards for IVT mRNA manufacturing and neuro-therapeutic drug development.
1. What Is Cytidine 5′-Triphosphate Disodium Salt and Its Core Biochemical Value
Cytidine 5′-triphosphate disodium salt (shortened as CTP disodium or 5′-CTP 2Na) ranks among the four core ribonucleoside triphosphates that support all natural RNA biosynthesis pathways. Its molecular structure combines a cytosine base, a ribose sugar, and three phosphate groups, stabilized via two sodium ions to form an easy-to-store crystalline powder. Unlike the unstable free CTP acid, the disodium salt form delivers a balanced neutral pH and outstanding water solubility, making it the dominant commercial specification for global biotech laboratories and pharmaceutical manufacturers.
Irreplaceable Dual Core Roles in Biological Reactions:
- Substrate for IVT: It acts as a fundamental building block for all RNA polymerases during In Vitro Transcription (IVT).
- Phosphate Donor: It serves as the key donor for phospholipid and glycoconjugate synthesis in cell metabolism.
For bulk purchasing managers and lab R&D directors, understanding grade differences directly determines experimental success rates and finished drug quality. This explains why most qualified buyers prioritize anhydrous CAS 36051-68-0 over hydrate variants for high-standard projects.
⚠️ Buyer Differentiation Note: Many first-time buyers confuse CTP disodium with CMP or CDP derivatives. CMP only carries one phosphate group and cannot support full-length RNA synthesis; CDP lacks sufficient energy supply for phospholipid activation. Only the triphosphate-structured CTP disodium provides the triple phosphate energy chain required for both IVT and cellular membrane repair reactions.
2. Three Main Application Scenarios of High-Purity CTP Disodium Salt
■ 2.1 In Vitro Transcription & mRNA Therapeutic Raw Material Supply
The booming mRNA vaccine and gene therapy industry has created a surging demand for nuclease-free CTP disodium. Molecular biology grade CTP disodium with ≥98% HPLC purity removes DNase, RNase, and residual phosphatase that would break synthetic RNA strands during transcription. Lab teams mix CTP disodium with matching ATP, GTP, and UTP to set up T7 or SP6 polymerase
IVT systems
to produce mRNA, gRNA, and siRNA for CRISPR gene editing, tumor gene treatments, and vaccine research.
Low-quality CTP batches frequently lead to low RNA yields and severe strand degradation. Our factory’s enzyme synthesis process eliminates the protein residues commonly found in chemical synthesis CTP products, cutting RNA degradation risks by over 40%. Small trial packs (100mg to 1g) satisfy university labs, while 25kg bulk drums support large-scale industrial mRNA pilot lines.
■ 2.2 Pharmaceutical Injection Raw Material for Neurological Drugs
Pharmaceutical injection grade CTP disodium complies with strict injectable raw material testing standards, featuring ultra-low bacterial endotoxin and heavy metal limits. As a clinically approved
nucleotide coenzyme,
this compound fuels energy metabolism inside damaged nerve cells, accelerates phospholipid synthesis on nerve membranes, and speeds up recovery after brain trauma, cerebral infarction, and peripheral nerve injuries.
■ 2.3 Industrial Biochemical Fermentation and Lipid Metabolism Research
Industrial fermentation factories select 95% purity CTP disodium as a catalytic substrate for microbial phospholipid and sialic acid derivative production. In academic research labs focused on lipid biology, researchers use CTP disodium to analyze phosphatidylcholine synthesis pathways and purinergic receptor signaling mechanisms for new drug target screening. This grade relaxes endotoxin restrictions to lower bulk costs for large-volume industrial bioreactors.
3. Key Grade Selection Standards for Bulk Buyers
| Core Criterion | Requirements & Selection Logic |
|---|---|
| 1. End-Use Application | Injectable drug production and human cell mRNA experiments require Anhydrous Pharmaceutical Grade (CAS 36051-68-0). Basic academic research and non-sterile fermentation can utilize lab or hydrate technical grades to save budget. |
| 2. Critical Impurity Limits | Nuclease-free testing is non-negotiable for all RNA projects. Endotoxin levels <0.1 EU/mg are mandatory for human cell contact. Avoid low-cost suppliers who skip these crucial validation tests. |
| 3. Storage & Logistics | Pharma manufacturing requires anhydrous powder because the fluctuating water content in hydrate forms alters formula concentration. Cold-chain transport is recommended for cross-border ocean shipping to prevent hydrolysis. |
4. Factory Supply Advantages Benefiting Long-Term B2B Partners
As a direct nucleotide raw material manufacturer running independent, stable
enzyme synthesis production lines,
we deliver three fundamental competitive edges for global B2B procurement teams:
📈 Continuous Stock Capacity
Our workshop maintains a non-stop daily manufacturing schedule. We secure immediate stock ranging from trial samples to tons-level framework contracts, bypassing middleman delays.
📄 Complete Document Support
Every shipment includes batch-specific COA, SDS, COO, and endotoxin/impurity test sheets. We dynamically adjust test items to comply with EU, US, and FDA import registration rules.
⚙️ Flexible Customization
We customize purities from 95% to 99%, provide pre-mixed nucleotide solutions (ATP/CTP/GTP/UTP), design private labels, and offer locked-in annual pricing contracts.
5. Storage & Handling Best Practices to Extend Shelf Life
⚠️ Critical Notice: CTP disodium possesses high hygroscopicity and hydrolyzes rapidly upon moisture absorption.
- Long-Term Storage: Unopened original packages must be kept at -20℃, isolated from light and moisture, ensuring a 36-month shelf life.
- After Opening: Aliquot the powder into small single-use vacuum sub-packs immediately to reduce ambient air exposure. Consume all opened material within 30 days.
- Avoid Thermal Fluctuations: Repeated freeze-thaw cycles break crucial phosphate bonds, turning the active ingredient into degraded CMP and CDP impurities.
- Aqueous Working Solutions: Always prepare solutions fresh immediately before starting IVT setups. For necessary short-term storage, keep at -20℃ and use within 7 days. Always wear disposable nitrile gloves and dust masks during weighing operations.
6. Conclusion: Your Reliable Direct Supplier for Advanced Biotechnology
Cytidine 5′-triphosphate disodium salt remains an irreplaceable foundational nucleotide across mRNA therapy, neurological drug formulation, and high-end biochemical research fields. Partnering directly with a factory utilizing enzymatic synthesis technology ensures absolute batch consistency, complete regulatory clarity, and optimized factory-direct pricing.
Ready to secure a stable supply of CTP Disodium Salt for your pipeline?
Whether you require 100mg lab samples for screening, kilogram batches for clinical pilots, or bulk drums for full-scale commercial manufacturing, our technical sales experts are ready to assist with custom documentation and logistics.
