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CDP-Na₂ CAS：54394-90-0
Factory-grade cytidine 5′-diphosphate disodium salt CDP-Na₂ with HPLC purity 98%–99.5%. This key nucleotide intermediate manufactures citicoline raw material, supports cell culture & biochemical enzyme assays, stable low-impurity bulk stock for biopharma buyers.
Product Specs
Disodium Cytidine 5′-Diphosphate (CDP-Na₂) | CAS 54394-90-0
1. Basic Chemical Identification
| Synonyms | Disodium cytidine 5′-diphosphate, CDP-Na₂ |
| CAS No. | 54394-90-0 |
| MDL Number | MFCD00069770 |
| HS Code | 2934999099 |
| Molecular Formula | C₉H₁₃N₃Na₂O₁₁P₂ |
| Molecular Weight | 447.14 g/mol |
| InChI Key | MAGSIBHRUIBONY-UHFFFAOYSA-N |
2. Physical & Chemical Properties
- Appearance: White to off-white crystalline powder.
- Hygroscopy: Strongly hygroscopic, must be airtight sealed.
- Solubility: Freely soluble in purified water; insoluble in ethanol, acetone, ether, and chloroform.
- 1% Aqueous pH Value: 7.2–8.2
- UV Absorption Peak: λmax = 271 nm
- Stability Note: Solid form is highly stable under -20°C dry dark storage. Aqueous solution easily hydrolyzes at room temperature and degrades to CMP and cytidine under strong acid or high temperature.
3. Quality Control Index (COA Full Data)
| Test Items | Specification / Standards |
|---|---|
| 1. HPLC Assay | 98.0% / 99.0% / 99.5% (Optional grades) |
| 2. Single Unknown Impurity | ≤ 0.5% |
| 3. Total Impurities | ≤ 1.0% |
| 4. Water Content (Karl Fischer) | ≤ 1.5% (Anhydrous grade) | ≤ 8.0% (Hydrated grade) |
| 5. Heavy Metals (Pb, As, Cd, Hg) | ≤ 10 ppm |
| 6. Bacterial Endotoxin | < 10 EU/mg (Pharmaceutical Intermediate Grade) |
| 7. Residue on Ignition | 28.0% – 32.0% |
| 8. Chloride & Sulphate | Meets biochemical reagent limit standards |
4. Detection & Verification Methods
Content Quantification Reverse-phase HPLC-UV
Structure Confirmation ¹H-NMR, ³¹P-NMR, ESI Mass Spectrometry
Moisture Testing Karl Fischer titration
Endotoxin Detection LAL turbidimetric method
5. Standard Packaging & MOQ
- Lab Package: 1g, 5g, 10g, 50g (Vacuum aluminum foil bag)
- Industrial Bulk: 1kg inner vacuum bag + PE outer bag; 25kg fiber drum with double aluminum liners.
- Customized Options: 50kg drum, ton bag customization available.
- MOQ: 1kg (Bulk volume discount over 25kg)
6. Storage & Transportation Guidelines
- Long-term (>6 months): Store at -20°C, dry, dark, airtight sealed with desiccant. Shelf life: 24 months.
- Short-term (1–3 months): 2–8°C refrigeration; avoid frequent opening.
- Aqueous Solution: Prepare before use. Stable at 4°C for 7 days, or -20°C for 30 days (Avoid repeated freeze-thaw cycles).
- Logistics: Non-dangerous chemical goods. Cold-chain ice pack transport is required for summer long-distance delivery to avoid hydrolysis.
7. MSDS Safety Operation Rules
⚠️ Classification: Low-toxic biochemical raw material. Non-corrosive, non-flammable, non-explosive.
- Skin Contact: Rinse with clean water immediately; for large area contact, use neutral detergent.
- Eye Splash: Flush continuously with clear water for at least 15 minutes. Seek prompt medical advice if irritation persists.
- Powder Handling: Wear professional dust masks during operation to prevent dust inhalation.
- Prohibited Co-storage: Keep strictly away from strong acids, strong alkalis, and strong oxidants.
- Waste Disposal: Small quantities can be dissolved in water for normal liquid waste discharge; large volumes of solid waste must be handed over to certified professional biochemical waste treatment agencies.
8. Why Choose Us? Factory Production Advantages
🏭
15+ Years Expertise
15+ Years Expertise
Operating an independent nucleotide synthesis workshop with deep manufacturing experience.
🔬
In-House Testing Lab
In-House Testing Lab
Equipped with high-end HPLC & NMR labs. Free COA, MSDS, and full spectrum documents provided.
🛡️
Pharma-Grade Standards
Pharma-Grade Standards
Strict endotoxin control, custom-tailored for professional citicoline intermediate clients.
⚡
Fast & Flexible Supply
Fast & Flexible Supply
Stable monthly bulk output with 3–7 working days fast lead time. Custom purity, packaging, and moisture index supported.
FAQ
Cytidine 5′-Diphosphate Disodium Salt (CDP-Na₂) – Frequently Asked Questions
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Cytidine 5′-Diphosphate Disodium Salt CDP-Na₂: Complete Guide for Biopharma & Lab Raw Material Buyers
Premium Nucleoside Diphosphate Nucleotide Raw Material | CAS 54394-90-0
🔑 Executive Summary:
Cytidine 5′-diphosphate disodium salt (CDP-Na₂) is a vital nucleoside diphosphate nucleotide raw material widely demanded by biopharmaceutical factories and life science laboratories worldwide. It occupies an irreplaceable position in phospholipid biosynthesis and pharmaceutical intermediate manufacturing, especially for bulk buyers seeking high-efficiency production pathways.
1. Basic Overview & Core Chemical Properties of CDP Disodium Salt
Many global procurement managers search for low-impurity bulk CDP disodium salt every month to power their synthesis lines. Understanding its fundamental chemical architecture is critical for successful long-term quality control.
| Property / Identifier | Technical Data & Reference Links |
|---|---|
| Chemical Name | Cytidine 5′-(trihydrogen diphosphate), sodium salt (1:2) |
| CAS Number | 54394-90-0 (CAS Common Chemistry) |
| Molecular Formula | C₉H₁₃N₃Na₂O₁₁P₂ |
| Molecular Weight | 447.14 g/mol (Anhydrous powder via PubChem) |
| 1% Aqueous pH Value | 7.2 – 8.2 |
⚠️ Stability & Structural Warning for Logisticians:
A critical structural feature is the pyrophosphate linkage in its molecular chain. This high-energy bond supports CDP-Na₂ to act as an activated carrier molecule inside biochemical pathways, yet the same bond breaks down under high heat, strong acid, or prolonged air exposure. Unlike monophosphate cytidine (CMP) or triphosphate cytidine (CTP), CDP disodium salt contains exactly two phosphate groups, matching the precise structural requirement for citicoline condensation production. Its strong water absorption capacity means qualified suppliers must adopt vacuum aluminum foil packaging and cold-chain delivery.
A critical structural feature is the pyrophosphate linkage in its molecular chain. This high-energy bond supports CDP-Na₂ to act as an activated carrier molecule inside biochemical pathways, yet the same bond breaks down under high heat, strong acid, or prolonged air exposure. Unlike monophosphate cytidine (CMP) or triphosphate cytidine (CTP), CDP disodium salt contains exactly two phosphate groups, matching the precise structural requirement for citicoline condensation production. Its strong water absorption capacity means qualified suppliers must adopt vacuum aluminum foil packaging and cold-chain delivery.
2. Industrial Commercial Applications of High Purity CDP-Na₂ for B2B Buyers
The industrial utility of cytidine 5′-diphosphate disodium salt segments clearly across high-volume production lines and precision laboratory applications:
🏭 Mass Production of Citicoline
In the classic Kennedy lipid synthesis pathway, CDP-Na₂ condenses with phosphocholine under specific enzyme catalysis to generate finished citicoline raw materials. Citicoline (CDP-choline) is a mainstream clinical neuroprotective drug used to treat brain injury, stroke sequelae, and cognitive decline disorders. Pharmaceutical manufacturers with GMP lines require consistent, low-endotoxin CDP disodium salt with HPLC purity above 99% to comply with global drug registration standards.
🔬 Laboratory & Diagnostic Biotech R&D
It serves as the exclusive specific substrate of CDP nucleoside diphosphate kinase, converting CDP into CTP to fuel advanced DNA and RNA synthesis research. Ribonucleotide reductase testing, cell culture medium formulation, and liposome drug delivery system development all rely heavily on stable batches. Furthermore, diagnostic kit manufacturers add CDP-Na₂ as a core reaction substrate for in vitro enzymatic detection reagents.
Selection Blueprint Based on Purity Grades:
≥98% Biochemical Grade: Small-scale academic labs, routine metabolic pathway experiments, and cell culture testing.
≥99% Pharma Intermediate Grade: Biopharma factories, bulk Citicoline synthesis, and continuous GMP production lines.
≥99.5% Reference Standard Grade: New drug R&D labs, strict spectrum calibration, and compound structural verification.
3. Key Quality Control Standards That Qualified CDP Disodium Salt Manufacturers Must Follow
Global pharmaceutical procurement teams rank impurity control as the top evaluation index when selecting suppliers. Uncontrolled related substances like residual CMP or free cytidine directly lower conversion yields and increase downstream purification expenses.
4. Storage, Packaging & Cross-Border Shipping Tips for Bulk CDP-Na₂ Orders
Due to strong hygroscopicity, improper storage is the most common cause of quality degradation reported by overseas buyers. Follow these parameters strictly to protect your active inventory:
❄️ Storage Temperature Guide
- Long-term Stock (>6 Months): Constant -20°C in dark, dry warehouses with internal desiccant.
- Short-term Workshop Storage: Between 2°C and 8°C (Valid for batches used within 3 months).
- Opened Packaging: Must be resealed tightly and fully consumed within half a year.
- Aqueous Mother Liquids: Highly prone to hydrolysis. Prepare fresh before each single experiment.
📦 Packaging Configurations & Logistics
- Lab Test Samples: 1g – 50g vacuum aluminum foil bags.
- Industrial Bulk Shipments: 1kg inner foil bags or 25kg fiber drums lined with double moisture-proof aluminum foil. (Custom 50kg drums or flexible ton bags available).
- Tropical / Summer Sea Freight: Requires ice bag cold chain packaging to prevent ambient heat from triggering caking. Classified as non-hazardous general chemical goods.
5. How to Select Reliable Factory Suppliers for Cytidine 5′-Diphosphate Disodium Salt
Experienced B2B chemical procurement managers focus on four core supplier credentials before placing large bulk orders of CDP-Na₂ to eliminate raw material production risks:
📌 1. Independent Nucleotide Synthesis Workshop: Confirm you are dealing with actual factories rather than third-party resellers. Self-owned manufacturing lines assure superior batch-to-batch stability and direct cost controls.
🔬 2. In-House Testing Laboratory: Ensure the facility is equipped with real-time in-house HPLC and NMR instruments to eliminate outsourcing testing delays.
📄 3. Comprehensive Document Packages: Reliable partners must provide formal COAs, MSDSs, customs certificates of origin, and complete spectrum files free of charge with each shipment.
⚙️ 4. Customization Capacities: Flexible purity settings, adjustable moisture indexes, and tailored packaging must be available to match unique laboratory or pharmaceutical manufacturing requirements.
Looking for a Trusted Bulk CDP-Na₂ Manufacturer?
Established manufacturers with over 10 years of nucleotide expertise offer stable monthly output, short lead times (3–7 working days), and tiered volume discounts for orders above 25kg.
Contact Our Sales Team for a Batch-Specific Quote & Free Sample
Conclusion
Cytidine 5′-diphosphate disodium salt (CDP-Na₂ CAS 54394-90-0) remains an irreplaceable foundational nucleotide raw material for citicoline pharmaceutical manufacturing and global life science research labs. Overseas B2B buyers can avoid production loss and quality disputes by selecting factory suppliers with strict impurity control, complete testing documentation, and standardized moisture-proof cold-chain logistics solutions. Matching your selected CDP-Na₂ purity grade to specific production or experimental scenarios directly optimizes production efficiency and long-term raw material procurement costs for every biopharma and laboratory enterprise.
