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GMP CAS：5550-12-9
Disodium 5′-Guanylate (5′-GMP disodium, E627) is a high-purity nucleotide umami enhancer produced via microbial fermentation. Our factory supplies food-grade white crystalline powder complying with GB, FDA, EFSA & HACCP standards. It delivers strong mushroom umami and creates powerful flavor synergy with MSG & disodium inosinate (IMP, I+G blend). Widely used in seasonings, instant food, meat processing and canned goods. Stable, water-soluble, low additive dosage and fully traceable production. We offer flexible MOQ, full COA documents and global bulk shipping for food manufacturers, seasoning factories and ingredient distributors worldwide.
Premium Disodium 5′-Guanylate (E627) Core Specifications & Advantages
Factory Direct
⏳ Shelf Life & Quality Stability: Extended 24-month shelf life with superior stable storage.
✓ CONSISTENT BATCH QUALITY FOR LARGE-SCALE FOOD MANUFACTURING
Product Specs
Guanosine 5′-Monophosphate Disodium Salt (Disodium 5′-Guanylate)
Basic Chemical Identification
| Item | Full Standard Parameter |
|---|---|
| Full Chemical Name | Guanosine 5′-Monophosphate Disodium Salt (Disodium 5′-Guanylate) |
| Short Aliases | 5′-GMP Disodium, GMP 2Na, E627 |
| CAS Number | 5550-12-9 |
| EINECS No. | 226-914-1 |
| Molecular Formula | C₁₀H₁₂N₅Na₂O₈P·7H₂O (heptahydrate industrial grade) |
| Anhydrous Molecular Weight | 407.18 |
| HS Customs Code | 2934999090 |
| Food Additive INS Code | E627 |
Physical & Chemical Properties
- 1. Appearance: White or colorless crystalline powder, odorless, natural mushroom umami taste.
- 2. Solubility: Highly soluble in cold & warm water; slightly soluble in ethanol; insoluble in acetone and grease.
- 3. 5% Aqueous Solution pH: 7.0–8.5
- 4. Optical Rotation [α]₂₀ᴰ: +20.0° ~ +22.0°
- 5. Thermal Stability: Stable under neutral/weak alkaline processing; avoid long-time heating under pH＜5 acidic environment (easy hydrolysis, lose umami activity).
- 6. Hygroscopicity: Moderate moisture absorption, airtight packaging required for long-term storage.
Food Grade Quality Standard (GB 1886.170-2016 / FCC / EFSA Regulation)
• Assay (dry basis): 97.0% – 102.0%
• Loss on drying (heptahydrate): ≤25.0%
• Heavy metals (Pb): ≤10 ppm
• Arsenic (As): ≤4 ppm
• Ammonium salt, related nucleotides: Compliant, no impurity interference
• UV absorbance ratio: 250/260=0.94~1.04, 280/260=0.63~0.71
Production Technology & Factory Advantages
Our disodium 5′-guanylate adopts pure microbial fermentation route using corn starch as raw material, different from low-purity RNA hydrolysis products. Whole production line ISO22000 & BRC certified, full online quality inspection for every batch. We support third-party lab testing and provide full traceability records from raw material fermentation to finished crystallization.
Industrial Application Scenarios (B2B Buyer Guide)
1. Seasoning Raw Material:
Chicken powder, compound seasoning, hot pot base, soy sauce, oyster sauce.
Chicken powder, compound seasoning, hot pot base, soy sauce, oyster sauce.
2. Processed Meat & Seafood Products:
Ham, sausage, canned fish, frozen meat products.
Ham, sausage, canned fish, frozen meat products.
3. Instant Food Raw Material:
Instant noodle seasoning packet, self-heating hot pot soup base.
Instant noodle seasoning packet, self-heating hot pot soup base.
4. Snack & Savory Food:
Potato chips, puffed savory snacks, jerky marinade.
Potato chips, puffed savory snacks, jerky marinade.
5. Auxiliary Raw Material:
Cell culture medium, oral nutrient solution, nucleotide pharmaceutical intermediate.
Cell culture medium, oral nutrient solution, nucleotide pharmaceutical intermediate.
Recommended Dosage Reference for Food Manufacturers
Mixed with MSG only
2% – 5%
of monosodium glutamate weight
I+G Compound (1:1 IMP & GMP)
0.05% – 0.15%
of total food weight
Pure Disodium 5′-Guanylate Single Use
0.01% – 0.08%
of total food weight
Packaging, Storage & Transportation
📦 Packaging Options
• Sample: 1kg vacuum aluminum foil bag
• Bulk industrial: 25kg fiber drum with double PE inner liner
• Custom small batch: 5kg / 10kg on demand
• Sample: 1kg vacuum aluminum foil bag
• Bulk industrial: 25kg fiber drum with double PE inner liner
• Custom small batch: 5kg / 10kg on demand
☀️ Storage Conditions
Cool, dry, dark warehouse. Relative humidity below 60%. Keep fully sealed after opening.
Cool, dry, dark warehouse. Relative humidity below 60%. Keep fully sealed after opening.
⏳ Shelf Life
• 24 months unopened
• Use within 6 months once unsealed
• 24 months unopened
• Use within 6 months once unsealed
🚚 Transport Guide
Non-dangerous goods. Keep away from strong acid, rain, and moisture during shipment.
Non-dangerous goods. Keep away from strong acid, rain, and moisture during shipment.
FAQ
Q1
What is the difference between disodium 5′-guanylate and I+G flavor enhancer?
Disodium 5′-guanylate (GMP E627) is a single-component nucleotide enhancer. I+G is a 1:1 mixture of disodium inosinate (IMP E631) and disodium guanylate (GMP). The 1:1 I+G blend delivers stronger umami synergy than single GMP powder. Most seasoning factories choose I+G for cost optimization, while clients requiring pure mushroom flavor select standalone disodium 5′-guanylate.
Q2
Is food grade disodium 5′-guanylate safe for global food market export?
Yes. Our product meets FDA, EFSA, GB national food standard, and FCC specifications. FAO/WHO JECFA sets no restricted ADI limit for E627. We provide Halal, Kosher, HACCP, and ISO22000 certification documents for customs clearance in EU, US, Southeast Asia, and Middle East markets. Note: It is prohibited only in infant formula per EU regulations.
Q3
Will disodium 5′-guanylate decompose during high-temperature food sterilization?
Under neutral and weak alkaline pH (6.5–8.5), it keeps stable under 121℃ high-temperature sterilization. If the food formula pH is lower than 5 (strong acid environment like vinegar marinade), long-time boiling will break the phosphate ester bond and lose the umami effect. We suggest adding GMP after high-temperature cooking for acidic food production lines.
Q4
What MOQ do you support for bulk disodium 5′-guanylate orders?
Our minimum order quantity is 1kg for lab testing samples; formal bulk wholesale orders start from a 25kg full drum. Large food manufacturers with a monthly demand above 1 ton can get tiered FOB factory price discounts. Our stable monthly production capacity of 120 tons ensures a continuous supply without stock shortages.
Q5
How to distinguish fermentation-grade GMP from low-quality RNA hydrolysis GMP?
Fermentation-grade disodium 5′-guanylate has higher purity (≥99%), fewer impurity nucleotides, and a stable batch-to-batch taste. RNA hydrolysis products contain mixed nucleotide impurities, making it easy to produce a bitter aftertaste in finished food. Our COA reports include UV absorbance ratio testing data to prove pure fermentation-grade raw material.
Q6
Can disodium 5′-guanylate be used in low-sodium food formulations?
Absolutely. Because GMP has extreme umami enhancement capability, manufacturers can reduce total MSG and salt addition by 40%–65%. Even with a low-sodium formula, a rich savory flavor can be maintained without extra salt, making it ideal for low-sodium healthy seasoning product lines.
Q7
What documents will you provide for customs and factory quality inspection?
Every shipment comes with a full set of documents: Certificate of Analysis (COA), factory production certificate, MSDS safety data sheet, commercial invoice, packing list, and requested food certification (Halal/Kosher) as per the buyer’s requirement. All documents support customs inspection and third-party lab re-testing.
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Disodium 5′-Guanylate E627: Complete Guide for Food Manufacturers to Source Bulk Fermentation Grade GMP Disodium
1. What Is Disodium 5′-Guanylate E627 and How It Creates Superior Umami Flavor
Disodium 5′-Guanylate, commonly shortened as 5′-GMP disodium or E627, is a premium nucleotide-based flavor enhancer widely adopted by global food processing plants and seasoning manufacturers. Derived from natural microbial fermentation, this white crystalline powder carries an intense natural mushroom umami profile that cannot be replicated by single monosodium glutamate (MSG) alone.
💡 The Core Functional Advantage: Umami Amplification
When blended with MSG, the combined savory taste increases exponentially rather than linearly. Only 2% to 5% GMP disodium relative to MSG weight can multiply food umami intensity 3 to 4 times. For B2B ingredient buyers, this cost-saving characteristic makes food grade disodium 5′-guanylate an essential additive to cut raw material costs in factory mass production.
Many new food factory buyers confuse disodium guanylate with synthetic flavor boosters. It is critical to clarify that top-tier fermentation-grade disodium 5′-guanylate uses corn starch as the fermentation substrate, making it fully biodegradable and free of toxic chemical residues. Its natural nucleotide structure matches the umami compounds found in shiitake mushrooms, kelp, and aged meat, delivering a layered, long-lasting savory taste without any artificial chemical aftertaste.
2. Key Physical & Quality Specifications for Bulk Disodium 5′-Guanylate Factory Sourcing
When purchasing wholesale disodium 5′-guanylate from Chinese manufacturers, professional food ingredient buyers prioritize strict quality indicators aligned with international food safety standards.
🔑 Core Identifier
CAS 5550-12-9
Ensures you avoid impure substitute nucleotide materials.
CAS 5550-12-9
Ensures you avoid impure substitute nucleotide materials.
🧪 Purity Range
97.0% – 102.0%
Calculated on a dry basis; a non-negotiable index for export lines.
97.0% – 102.0%
Calculated on a dry basis; a non-negotiable index for export lines.
💧 Fast Solubility
Dissolves within 10s
Leaves transparent liquid without sediment; prevents pipeline blockage.
Dissolves within 10s
Leaves transparent liquid without sediment; prevents pipeline blockage.
🔥 Thermal Stability
Up to 121°C Retort
Maintains full activity under neutral/weak alkaline sterilization.
Up to 121°C Retort
Maintains full activity under neutral/weak alkaline sterilization.
Reputable factories will attach complete COA reports with UV absorbance ratio test results. This is the most reliable method to verify genuine 5′-GMP disodium and eliminate mixed impurity nucleotides from cheap, inferior alternatives.
3. Main Commercial Applications of Food Grade Disodium 5′-Guanylate in Global Food Production
Bulk disodium 5′-guanylate serves four major B2B industrial segments, covering nearly all savory processed food categories with high umami demand:
1. Compound Seasoning Manufacturing (Largest Sector)
Chicken essence powder, hot pot base seasoning, fermented soy sauce, and oyster sauce factories rely on E627 to enhance deep mushroom savory notes. Seasoning distributors buying 1-ton bulk drums often combine it with disodium inosinate to produce finished I+G flavor enhancers.
Chicken essence powder, hot pot base seasoning, fermented soy sauce, and oyster sauce factories rely on E627 to enhance deep mushroom savory notes. Seasoning distributors buying 1-ton bulk drums often combine it with disodium inosinate to produce finished I+G flavor enhancers.
2. Processed Meat & Aquatic Canned Food
Used to mask fishy, metallic, and bitter off-notes from raw meat and seafood. Ham, sausage, canned tuna, and frozen shrimp marinades with low GMP dosage present a richer meaty umami without raising excessive sodium content, complying with global low-sodium food market trends.
Used to mask fishy, metallic, and bitter off-notes from raw meat and seafood. Ham, sausage, canned tuna, and frozen shrimp marinades with low GMP dosage present a richer meaty umami without raising excessive sodium content, complying with global low-sodium food market trends.
3. Instant Food Raw Materials
Integrated into seasoning oil and soup packets for instant noodles, self-heating rice, and portable hot pots. The long shelf-life stability of sealed GMP powder matches the 18–24 month shelf life requirement of instant consumer goods.
Integrated into seasoning oil and soup packets for instant noodles, self-heating rice, and portable hot pots. The long shelf-life stability of sealed GMP powder matches the 18–24 month shelf life requirement of instant consumer goods.
4. Niche Biotech & Pharmaceutical Industrial Uses
Includes cell culture medium raw materials for biotech labs and oral nutritional liquid intermediates for health supplement factories. These high-purity special grades require stricter heavy metal limits and zero microbe standards, manufactured in dedicated clean workshops.
Includes cell culture medium raw materials for biotech labs and oral nutritional liquid intermediates for health supplement factories. These high-purity special grades require stricter heavy metal limits and zero microbe standards, manufactured in dedicated clean workshops.
4. Fermentation Grade vs RNA Hydrolysis Disodium 5′-Guanylate: Critical Differences
The gap in quality, taste, and export compliance between the two mainstream production routes is massive for cross-border food manufacturers sourcing bulk E627:
❌ RNA Hydrolysis Grade GMP
- Produced by breaking down yeast ribonucleic acid with enzymes.
- Contains unavoidable mixed impurities (uridine, cytidine nucleotides).
- Easy to produce a bitter, metallic aftertaste in finished foods.
- Fails strict EU food additive residue testing, limiting export access.
👑 Pure Fermentation Grade (Our Standard)
- Synthesizes guanosine via engineered bacterial fermentation.
- Zero extra nucleotide impurities; clean, pure mushroom umami.
- Fully compliant with FDA, EFSA, Halal, and Kosher standards.
- Guarantees smooth customs clearance and stable batch flavor consistency.
5. Global Bulk Sourcing Guide for Disodium 5′-Guanylate Factory Direct Orders
To select reliable Chinese GMP disodium manufacturers and avoid low-quality counterfeit raw materials, verify these four essential checkpoints:
- Verify Factory Production Capacity: Trustworthy suppliers maintain a monthly output above 80 tons, with independent crystallization and purification production lines instead of third-party blending outsourcing.
- Confirm Full Certification Packages: Mandatory documents include ISO22000, HACCP, FCC food chemical standards, and optional Halal/Kosher for Muslim and Western market exports.
- Test Samples Before Large Bulk Shipments: We offer 1kg free testing samples with full COA reports for factory R&D teams to conduct water solubility, umami taste, and high-temperature stability trials.
- Negotiate Tiered Pricing for Long-Term Contracts: Look for steep FOB price discounts for monthly orders over 1000kg, plus stable priority delivery to prevent raw material stockouts during peak seasons.
6. Storage, Transportation & Usage Tips to Extend Disodium 5′-Guanylate Shelf Life
⚠️ Critical Alert for Acidic Formulations (pH < 5)
If your food formula is acidic (e.g., vinegar marinades), strong acid combined with sustained boiling will break the phosphate molecular bond. This permanently eliminates the umami function of E627. Always add disodium 5′-guanylate AFTER high-temperature cooking steps in acidic lines. For neutral and alkaline formulas, it can be mixed into raw materials before sterilization without performance loss.
- 📦 Sealed Packaging: Unopened 25kg fiber drums maintain a 24-month shelf life under cool, dry warehouse conditions (<25°C, RH <60%). Once opened, seal tightly and use within 6 months to prevent rapid moisture absorption and agglomeration.
- 🚢 Ocean Shipping Safety: Classified as non-dangerous food additives. Our factory wraps each pallet with stretch film to resist seawater moisture and rain, marking clear moisture-proof and light-shield labels on all outer packaging.
