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GTP·2Na CAS：56001-37-7
Manufacturer supply high purity GTP disodium powder for mRNA synthesis, biopharma intermediates & molecular biology research. 3 grades available, full COA & low endotoxin, custom packaging & free sample support for global B2B buyers.
Guanosine 5′-Triphosphate Disodium Salt Core Highlights
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Chemical Profile & Method
• CAS No: 56001-37-7
• Production Craft: Advanced enzymatic synthesis raw material.
• Chemical Form: Highly stable, water-soluble disodium salt form.
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Three Industrial Grades
• Research Grade: HPLC ≥ 99%
• Pharma Intermediate: HPLC ≥ 95%
• Fermentation Grade: HPLC ≥ 90%
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Strict Purity Control
• Zero Contamination: Guaranteed DNase & RNase-free for sensitive nucleic acid lab experiments.
• Ultra-low Impurities: Strictly controlled heavy metal and bacterial endotoxin levels.
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Downstream Applications
Ideal for In vitro transcription (IVT), compound liver protection APIs manufacturing, IVD molecular diagnostic kits production, and high-yield microbial amino acid fermentation.
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Standard Packaging
• Lab Trials: 1g secure aluminum foil bag.
• Pharma Bulk: 1kg inner vacuum aluminum foil bag.
• Industrial Mass: 25kg moisture-proof cardboard drum with double PE liner.
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Factory B2B Terms
Direct factory wholesale supply with flexible MOQ configuration. Fast global FOB port shipment supported. Full safety SDS and batch testing COA reports attached to every cargo.
Product Specs
Guanosine 5′-triphosphate disodium salt (GTP Na2)
Basic Chemical Identifiers
| Property | Value / Specification |
|---|---|
| Standard Name | Guanosine 5′-triphosphate disodium salt |
| Abbreviation | GTP Na2 / 5′-GTP Disodium |
| CAS Number | 56001-37-7 |
| Molecular Formula | C₁₀H₁₄N₅Na₂O₁₄P₃ (Anhydrous) |
| Molecular Weight | 567.14 |
| MDL / HS Code | MFCD00149227 / 2934999090 |
| UV Characteristic | λmax = 253 nm, A250/A260 = 1.15 (pH7 Buffer) |
Physical Properties
- Appearance: White crystalline powder with strong hygroscopicity.
- Solubility: Freely soluble in purified water; insoluble in ethanol, acetone, and ether.
- Aqueous pH (5% solution): 7.0–7.5 (Near physiological pH, ideal for cell experiments).
- Specific Rotation: [α]₂₀ᴰ +22° ~ +26° (0.1M Na₂HPO₄ buffer).
- Stability: Stable under sealed dry solid storage. Note: Aqueous solution hydrolyzes at room temperature.
Grade Standard Quality Index (Factory COA Standard)
1. Research Grade (HPLC ≥98%)
- GDP ≤ 1.0%, GMP ≤ 0.5%
- Inorganic phosphate ≤ 0.3%
- Heavy metals (Pb/As/Cd) ≤ 10ppm
- Endotoxin < 5 EU/mg
- No detectable RNase & DNase
- Water content ≤ 6.0%
2. Pharmaceutical Intermediate Grade (HPLC ≥95%)
- Total related impurities ≤ 5.0%
- Endotoxin < 10 EU/mg
- Heavy metals ≤ 20ppm
- Drying loss ≤ 8.0%
3. Fermentation Industrial Grade (HPLC ≥90%)
- Total impurities ≤ 10%
- Moisture ≤ 10%
- Food fermentation compliant
Our Production Technology & Advantages
Our GTP disodium adopts advanced bio-enzymatic catalytic synthesis instead of traditional chemical total synthesis. Under specific phosphate kinase catalysis, the raw material GMP undergoes multi-phosphorylation. It is then highly purified through strong alkaline anion exchange resin gradient elution, activated carbon decolorization, and low-temperature vacuum crystallization.
✔ Lowers impurity content by 40% compared to chemical synthesis.
✔ Significantly reduces hydrolysis risk.
✔ Supports stable, large-scale bulk production for pharma & biotech clients.
Packaging, Storage & Global Shipping
📦 Packaging Options
• Lab Trials: 100mg, 250mg, 1g, 5g vacuum aluminum foil bags.
• Pharma Bulk: 1kg inner aluminum foil vacuum bag.
• Industrial Bulk: 25kg cardboard drum with double PE liner + moisture barrier foil bag.
• Lab Trials: 100mg, 250mg, 1g, 5g vacuum aluminum foil bags.
• Pharma Bulk: 1kg inner aluminum foil vacuum bag.
• Industrial Bulk: 25kg cardboard drum with double PE liner + moisture barrier foil bag.
❄️ Storage Rules
• Short-term (1–3 months): 2–8℃ sealed away from moisture & light.
• Long-term (>6 months): -20℃ freezing. Avoid repeated freeze-thaw cycles.
• Shelf Life: 24 months unopened under standard storage.
• Short-term (1–3 months): 2–8℃ sealed away from moisture & light.
• Long-term (>6 months): -20℃ freezing. Avoid repeated freeze-thaw cycles.
• Shelf Life: 24 months unopened under standard storage.
✈️ Shipping & Logistics
Classified as a non-dangerous biochemical raw material. Available for regular sea and air freight. For bulk pharmaceutical orders, cold chain transport is highly recommended to guarantee maximum shelf life.
Classified as a non-dangerous biochemical raw material. Available for regular sea and air freight. For bulk pharmaceutical orders, cold chain transport is highly recommended to guarantee maximum shelf life.
Why Choose Us? Factory B2B Service Support
01. Free Samples: 10–50g free testing samples available for lab validation.
02. Customization: Custom purity adjustment & customized packaging labeling support.
03. Full Documentation: Batch COA, HPLC chromatogram, SDS, and endotoxin test report attached with each shipment.
04. Flexible MOQ: Small trial orders are highly acceptable before mass cooperation.
05. Technical Support: Professional chemical engineers provide formulation & storage guidance.
06. Fast Global Delivery: FOB Shanghai port delivery, with fast order replies within 24 working hours.
FAQ
Q1: What is the difference between GTP disodium and GTP trisodium salt?
GTP disodium aqueous pH stays neutral (7.0–7.5), perfectly matching the physiological environment. This makes it less cytotoxic for cell culture and in vitro transcription (IVT). In contrast, trisodium salt solution leans alkaline and is only suitable for general industrial fermentation. Most biotech labs and pharmaceutical manufacturers strictly choose the disodium grade.
Q2: Is your GTP disodium RNase-free for mRNA synthesis?
Yes. Our research grade GTP disodium undergoes a strict nuclease removal process—RNase & DNase are not detected in our test reports, making it fully compliant with sgRNA and mRNA in vitro transcription lab standards. Furthermore, our pharmaceutical grade meets ultra-low endotoxin requirements for nucleic acid drug intermediates.
Q3: How to store GTP disodium to avoid rapid hydrolysis?
The product is highly hygroscopic. Do not expose the powder to air for long periods after opening. We highly recommend splitting it into small centrifuge tubes for single use and storing it at -20℃ with a desiccant. Aqueous stock solutions should be prepared fresh before each experiment and cannot be stored longer than 48 hours at room temperature.
Q4: What downstream industries buy bulk GTP disodium raw material?
Our main bulk buyers include molecular biology reagent manufacturers, mRNA vaccine CRO/CDMO factories, liver protection API pharmaceutical plants, IVD nucleic acid diagnostic kit companies, and amino acid fermentation enterprises.
Q5: Can I get a custom COA matching local regulatory standards?
Yes, absolutely. Our factory supports customized test indicators according to EU, US, and Southeast Asia local import requirements. We provide full documentation including heavy metal, microbial, and endotoxin testing data to ensure smooth customs clearance.
Q6: What is the minimum order quantity (MOQ) for factory wholesale?
For initial lab validation, the trial sample MOQ is 100mg. Bulk industrial orders start at 1kg. For large-scale fermentation demand, we offer competitive, discounted tier prices for 25kg full drum orders.
Q7: Does GTP disodium require cold chain international shipping?
Small lab packages can be safely shipped at normal ambient temperatures within a 30-day transit window. However, for bulk pharmaceutical-grade shipments over 10kg, cold chain shipping is highly recommended to prevent any quality decline during long-distance sea transport.
Q8: Is GTP disodium a hazardous chemical for import customs?
No. This nucleotide raw material is classified as non-dangerous goods with no UN hazard classification. Regular chemical import procedures apply, and no special dangerous goods transport documentation is required.
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Industrial Grade Guanosine 5′-Triphosphate Disodium Salt: Complete Guide for Biotech & Pharma Bulk Buyers
Yoast SEO Quick Summary: Guanosine 5′-triphosphate disodium salt (CAS 56001-37-7) is a key nucleotide raw material for mRNA synthesis, pharma APIs, and fermentation. Our factory supplies three purity grades via enzymatic synthesis, with stable quality, full import documents, and custom packaging for global B2B biotech buyers. Free lab samples and 24-hour technical support available for bulk wholesale orders.
📄 Table of Contents
What Is Guanosine 5′-Triphosphate Disodium Salt (GTP Na2) and Its Core Biochemical Value
Guanosine 5′-triphosphate disodium salt, commonly shortened as GTP disodium, is a natural purine nucleoside triphosphate raw material registered under
CAS 56001-37-7.
Unlike crude GTP free acid, the disodium salt modification greatly improves water solubility and aqueous pH stability, making it the dominant raw material selected by global biotech labs and pharmaceutical manufacturers.
💡 Key Insight for B2B Procurement: Many overseas biotech procurement managers confuse GTP disodium with trisodium variants. From years of factory supply experience, we confirm that over 70% of mRNA synthesis and cell signaling research clients prefer the disodium salt. Its neutral water solution (pH 7.0–7.5) avoids pH interference with RNA polymerase activity, cutting experimental failure rates significantly.
Three Main Grades of GTP Disodium for Different Industrial Scenarios
Global downstream buyers select GTP disodium based on purity and impurity control standards. Our factory divides products into three targeted grades matching distinct production scenarios:
1. Research Grade (HPLC ≥98%)
Targets molecular biology labs, CRO institutions, and IVD reagent factories. This grade completely eliminates RNase, DNase, and excess inorganic phosphate. It is highly optimized for sgRNA synthesis, GTPase enzyme activity testing, and G-protein cell signaling pathway research.
2. Pharmaceutical Intermediate Grade (HPLC ≥95%)
Serves API manufacturers producing liver metabolism auxiliary drugs and ophthalmic neuroprotective preparations. Strict bacterial endotoxin control below 10 EU/mg ensures strict compliance with drug raw material import standards in the EU and US.
3. Industrial Fermentation Grade (HPLC ≥90%)
Used for microbial amino acid and antibiotic fermentation. It acts as an intracellular energy supplement to boost microbial metabolic efficiency, with relaxed impurity limits to aggressively lower bulk procurement costs for large fermentation plants with monthly ton-level demand.
Global Commercial Application Scenarios of Bulk GTP Disodium Raw Material
1. In Vitro Transcription & Nucleic Acid Research
This is the fastest-growing demand segment.
mRNA vaccine
and gene-editing labs require high-purity GTP disodium as one of four essential NTP monomers for RNA strand synthesis. Nuclease-free disodium salt prevents RNA degradation during transcription.
2. Biopharmaceutical API Manufacturing
GTP disodium acts as an active energy supplement raw material for compound hepatoprotective medicines, improving liver cell energy metabolism for chronic hepatitis adjuvant treatment. Ophthalmic pharmaceutical factories add this material to relieve retinal cell energy deficiency.
3. In Vitro Diagnostic (IVD) Kit Production
Nucleic acid amplification detection kits rely on GTP disodium as a critical reaction substrate for fluorescence quantitative testing. Manufacturers of clinical diagnostic reagents regularly buy bulk 1kg packages to reduce unit production costs for mass kit assembly.
4. Microbial Fermentation Industry
Large-scale fermentation factories add industrial grade GTP disodium to the culture medium, promoting bacterial strain proliferation and increasing the yield of target amino acids and antibiotics in biocatalyst production lines.
Key Factory Production Advantages of Enzymatic Synthetic GTP Disodium
Most small chemical suppliers adopt full chemical synthesis for GTP salt, which unfortunately brings high residual organic solvents and high GDP/GMP impurity levels. Our advanced factory enzymatic phosphorylation process uses GMP as a starting substrate, catalyzed by multi-phosphate kinase under a constant temperature, neutral buffer environment, fundamentally lowering related substance impurities.
- Seven-Stage Purification: Process includes anion exchange resin separation, activated carbon decolorization, gradient salt elution, and low-temperature vacuum crystallization.
- Extended Shelf Life: The finished powder gains stronger moisture stability, extending shelf life by 30% compared with chemically synthesized equivalents.
- Scale & Compliance: We maintain a stable monthly production capacity of over 3 tons, rigorously following
ISO quality standards, with independent testing labs providing HPLC, moisture, heavy metal, and endotoxin reports for each delivery.
Critical Storage & Transportation Guidelines for Bulk GTP Disodium Buyers
GTP disodium powder features strong hygroscopicity, which is the primary quality risk point for international bulk purchasers. Improper packaging during long sea shipping can cause unexpected product hydrolysis. Please strictly adhere to the following logistics and storage protocols:
❄️ Storage Environment
• Short-term (<3 months): Store in a 2–8℃ dry, sealed warehouse.
• Long-term (>6 months): Must be placed in a -20℃ cold storage room. Avoid repeated freeze-thaw cycles to minimize air moisture contact.
• Short-term (<3 months): Store in a 2–8℃ dry, sealed warehouse.
• Long-term (>6 months): Must be placed in a -20℃ cold storage room. Avoid repeated freeze-thaw cycles to minimize air moisture contact.
✈️ International Logistics
• Small Lab Samples: Regular air freight with integrated desiccant bags.
• Bulk Orders (>10kg Pharma Grade): Cold chain sea/air freight is highly recommended to maintain strict temperature controls during transit.
• Small Lab Samples: Regular air freight with integrated desiccant bags.
• Bulk Orders (>10kg Pharma Grade): Cold chain sea/air freight is highly recommended to maintain strict temperature controls during transit.
B2B Sourcing Standards and Factory Solutions
When sourcing bulk nucleotide raw materials globally, procurement teams must look for standardized verification to avoid supply chain disruptions. Here is how our factory addresses common challenges:
| Global Procurement Screening Standards | Our Standardized Factory Solutions |
|---|---|
| 1. Direct Factory vs. Middlemen Traders | We operate an independent enzymatic synthesis workshop, allowing us to flexibly adjust purity indicators and maintain complete batch-to-batch consistency. |
| 2. Full Pre-shipment Documentation | We attach an official COA, HPLC spectrum, SDS, and endotoxin test data with each shipment, fully compliant with international import customs auditing. |
| 3. Validation Before Mass Cooperation | We offer 10–50g free testing samples for laboratory validation to ensure our impurity profile matches your downstream process requirements perfectly. |
| 4. Multi-layer Moisture Protection | We implement double desiccant bags inside aluminum foil vacuum packaging, and wrap 25kg drums with outer waterproof film to prevent transit hydrolysis. |
Secure Your Bulk GTP Disodium Supply Chain Today
Connect directly with our chemical engineers for detailed formulation adjustment guidance, customized packaging, and tiered wholesale pricing sheets.
