Guanosine CAS：118-00-3

Guanosine (Guanine Ribonucleoside, CAS 118-00-3) is a natural purine nucleoside produced via microbial fermentation. Our factory provides food grade, pharmaceutical intermediate grade and cell culture reagent grade guanosine with HPLC purity ≥98.5%~99.5%. Widely used for disodium 5’-guanylate flavor enhancer and antiviral API synthesis, stable monthly output, free sample available for B2B bulk buyers.

Guanosine (CAS 118-00-3) Factory Direct Supply

High-purity purine nucleoside manufactured via industrial microbial fermentation. Premium raw material for food flavor enhancers (I+G) and pharmaceutical API synthesis.

Technical & Commercial Specifications

Core Keyword	Guanosine (CAS 118-00-3)
Appearance	White crystalline powder (Odorless)
Standard Purity	Food Grade ≥ 98.5% Pharma Grade ≥ 99.0% Reagent Grade ≥ 99.5%
Production Route	Industrial Microbial Fermentation (Ultra-low heavy metals & zero toxic organic solvents vs. chemical synthesis)
MOQ & Discount	1kg for sample trial \| 25kg for standard bulk order. ≥1000kg enjoys factory direct discount.
Certificates	ISO9001, GMP Workshop Standard, Batch COA, Regulatory MSDS, Heavy Metal & Microbe Test Report
Global Shipping	Sea Freight / Air Freight / Express door-to-door. Classified as Non-hazardous general cargo for fast customs clearance.
Packaging	1kg vacuum aluminum foil bag \| 25kg fiber drum with double PE plastic inner liners (Customized OEM packaging available)

Main Downstream Applications

1. Food Additive Field

Essential precursor to manufacture Disodium 5′-guanylate (GMP). Blended with IMP to form the I+G compound flavor booster to amplify umami profiles in processed food and savory seasonings.

2. Pharmaceutical & Biotech Field

Core upstream raw intermediate utilized to synthesize nucleoside antiviral APIs such as Acyclovir, Valacyclovir, Ganciclovir, Ribavirin, and nucleotide derivatives like GTP trisodium / cGMP.

Looking for a stable Guanosine factory supplier? Contact us for Free Samples (10g-100g) and the latest multi-ton tier pricing.

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Product Specs

Full Technical Specifications of Guanosine (CAS 118-00-3)

Discover the definitive technical, physical, and industrial profile of high-purity Guanosine, a critical nucleotide intermediate utilized globally across the pharmaceutical, food additive, and biotechnology sectors.

Basic Chemical Identity

English Name	Guanosine
Synonyms	Guanine ribonucleoside, 9-β-D-Ribofuranosylguanine
CAS Number	118-00-3
EINECS No	204-227-8
Molecular Formula	C₁₀H₁₃N₅O₅
Molecular Weight	283.24
IUPAC Name	2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one

Physical & Solubility Properties

Appearance: Odorless white crystalline powder
Melting Point: 240-250°C (Decomposes without boiling)
Optical Rotation: [α]_D²⁰ -60° (0.1M HCl solution)
UV Absorption Peak: 256nm (aqueous solution)
Solubility: Slightly soluble in cold water; freely soluble in hot water & dilute acid; insoluble in ethanol, acetone, and ether.
Moisture Absorption: Slight hygroscopicity; requires tightly sealed storage conditions.

Three Industrial Grade Standard Indexes

We supply three distinct, standardized grades of Guanosine manufactured strictly under rigorous quality control matrixes to match your precise application requirements:

Inspection Item	Food Grade Guanosine	Pharma Intermediate Grade	Cell Culture Reagent Grade
HPLC Purity	≥98.5%	≥99.0%	≥99.5%
Loss on Drying	≤0.5%	≤0.3%	≤0.1%
Residue on Ignition	≤0.1%	≤0.08%	≤0.05%
Lead (Pb)	≤10ppm	≤5ppm	≤1ppm
Arsenic (As)	≤1ppm	≤0.5ppm	<0.1ppm
Single Unknown Impurity	≤0.3%	≤0.1%	≤0.05%
Endotoxin	Unrequired	<0.5EU/mg	<0.1EU/mg
Microbe Count	≤100CFU/g	≤50CFU/g	Sterile Tested

Production Process: Fermentation Method Advantages

Our factory utilizes advanced engineered Bacillus subtilis fermentation production lines rather than conventional chemical synthesis or raw RNA hydrolysis. This premium bioprocess flows through 5 strategic stages:

Cultivation: High-purity glucose fermentation broth setup within precisely managed temperature & pH controlled bioreactor tanks.
Microfiltration: Complete elimination of bacterial biomass and complex macromolecule impurities.
Resin Purification: Cation and anion exchange resin chromatography to selectively isolate mixed nucleosides.
Recrystallization: Advanced hot water recrystallization methods to eradicate trace heterocyclic contaminants.
Drying & Packaging: Low-temperature vacuum drying paired with automated, dust-free cleanroom packaging.

factory Differentiator vs. Chemical Synthesis:

Our bio-fermented Guanosine delivers significantly lower heavy metal residue, exceptional natural purity, a reduced bulk cost footprint, and zero toxic chemical solvent waste—fully complying with global food additive and pharmaceutical-grade safety directives.

Critical Distinctions: Guanosine vs. Inosine vs. Adenosine

To assist procurement managers and B2B buyers in selecting the precise raw materials and avoiding costly manufacturing errors, here is the technical breakdown of the three primary purine nucleosides:

1. Guanosine (CAS 118-00-3)

Core Structure: Guanine + Ribose core characterized by a distinct C2 amino group.

Primary Applications: Downstream synthesis of disodium 5’-GMP and I+G umami flavor enhancers; core intermediate for Acyclovir, Valacyclovir, and cardiovascular GTP therapeutic agents.

Unique Advantage: The only nucleoside configuration capable of generating highly potent, umami-boosting nucleotide derivatives.

2. Inosine (CAS 58-63-9)

Core Structure: Hypoxanthine + Ribose configuration (lacks the C2 amino branch).

Primary Applications: Manufacturing of disodium 5’-IMP single flavor additives and mild neuroprotective pharmaceutical products.

Technical Limitation: Chemically incapable of generating guanine-based antiviral compound intermediates.

3. Adenosine (CAS 58-61-7)

Core Structure: Adenine + Ribose framework.

Primary Applications: Direct synthesis of ATP, adenosine injections for specific cardiac clinical treatments, and basic RNA laboratory transcription substrates.

Technical Limitation: Provides absolutely zero contribution to structural umami profile food synthesis.

Crucial Procurement Reminder: If your plant production targets focus on I+G flavor matrices or Acyclovir API series, Guanosine is completely irreplaceable. Attempting to substitute Inosine or Adenosine into these workflows will cause immediate batch failure.

Full Industrial Application Scenarios

Our bulk Guanosine supplies accommodate high-volume commercial production across several major industries:

1. Food Additive Manufacturing (High-Volume Demand)

Serves as the indispensable primary precursor for manufacturing disodium 5’-guanylate (GMP). When blended intentionally with disodium inosinate, it constructs the globally favored I+G super flavor enhancer widely formulated into instant noodle seasonings, premium canned meats, savory table sauces, bouillon cubes, and commercial snack seasonings.

2. Pharmaceutical API & Intermediate Synthesis

Functions as the core structural intermediate required to synthesize elite broad-spectrum antiviral medications including Acyclovir, Valacyclovir, Ribavirin, and Ganciclovir, as well as acting as the underlying base for GTP disodium and cGMP cyclic nucleotide cardiovascular therapeutics.

3. Biochemical Laboratories & Cell Culture Systems

Acts as a vital purine nutrient fortification supplement within mammalian cell culture media formulations, a precision substrate for in vitro RNA transcription, and a reliable reference standard reagent for methylation modification research assays.

4. Fine Chemical Custom Synthesis

Deployed extensively as an active building block for modified guanosine probe configurations, isotope-labeled nucleoside specialized derivatives, and biological diagnostics chemical kits.

Packaging, Storage & Global Shipping Specifications

Standard Packaging Configurations

Laboratory Samples: 10g, 50g, and 100g tightly sealed airtight aluminum bottles.
Small Bulk Volumes: 1kg heavy-duty vacuum-sealed aluminum foil bags.
Mass Industrial Production: 25kg rugged fiber drums lined with protective double PE inner liners.
*Customized OEM alternative packaging options are fully available upon request for authorized global distributors.

Storage & Preservation Rules

To maintain peak assay value over extended durations, stock material within a cool, dry warehouse environment consistently maintained ≤25°C. Ensure packages remain totally sealed, stored well away from direct sunlight exposure, and strictly isolated from strong acids or oxidizing agents. Under intact original factory sealing conditions, the certified shelf life spans 24 months.

Global Shipping Properties

Classified officially as non-dangerous chemical cargo, facilitating smooth, hassle-free clearance as general freight for ocean container shipping, air transport, or global express logistics courier lines. Each shipment comes wrapped in moisture-proof transit configurations and includes complete documentation (COA and detailed MSDS sheets) to guarantee uninterrupted customs clearance handling.

FAQ

Frequently Asked Questions: Guanosine Bulk Procurement & Applications

Get authoritative answers to the most common technical, regulatory, and purchasing questions regarding industrial Guanosine (CAS 118-00-3).

Q1
What is guanosine used for in food production?

Guanosine is the exclusive raw material used to manufacture disodium 5’-guanylate (GMP). Blending GMP with disodium inosinate creates the powerful I+G compound flavor booster, which drastically upgrades the umami taste profile of processed foods. It is widely utilized in savory seasonings to deliver a rich taste without any bitter aftertaste.

Q2
What purity grade guanosine do antiviral drug factories need?

Antiviral API production lines require Pharmaceutical Intermediate Grade Guanosine with an HPLC assay of ≥99.0%. To strictly meet GMP synthesis standards for Acyclovir and related nucleoside antivirals, a single unknown impurity must be tightly controlled under 0.1% alongside a minimized heavy metal index.

Q3
What is the difference between fermentation guanosine and chemical synthetic guanosine?

Fermentation Guanosine yields significantly lower heavy metal and solvent residues, achieves higher crystallization purity, is highly cost-effective for mass bulk orders, and is fully compliant with food-grade safety standards. Conversely, chemically synthesized guanosine often carries trace toxic organic solvents, rendering it suitable only for small-scale laboratory custom synthesis rather than large-scale food or pharma manufacturing.

Q4
Can I get a free guanosine sample before placing a bulk order?

Yes, we fully support the evaluation process. We provide complimentary 10g to 100g Guanosine samples for laboratory testing; buyers are only responsible for covering international shipping/courier costs. Every sample batch is accompanied by its corresponding batch COA (Certificate of Analysis) test report for your verification.

Q5
Is guanosine the same as inosine raw material?

No, they are distinct chemical entities. Guanosine and Inosine are different purine nucleosides featuring separate molecular structures and specialized downstream applications. Inosine is used primarily to produce IMP single-flavor enhancers, whereas Guanosine is required for GMP synthesis and broad-spectrum antiviral intermediates. Cross-substitution will result in complete product failure.

Q6
What certificates can you provide for bulk guanosine shipments?

We supply a comprehensive export documentation package to guarantee smooth customs clearance. This includes a comprehensive batch COA, full MSDS, ISO9001 certification, independent heavy metal & microbial test reports, commercial invoices, and detailed packing lists customized for EU, Southeast Asia, North America, and Middle East import regulatory frameworks.

Q7
What is the minimum order quantity (MOQ) for factory bulk guanosine?

Our baseline MOQ is 1kg to accommodate trial runs and pilot testing. For formal industrial manufacturing, standard sizing is 25kg per fiber drum. Commercial orders exceeding 1,000kg qualify for factory-direct bulk tier discounts and priority scheduling on our production lines.

Q8
How should guanosine be stored to avoid quality deterioration?

Guanosine must be kept tightly sealed in a cool, dry climate maintained consistently below 25°C, strictly avoiding high humidity and direct sunlight exposure. Unsealed or exposed powder readily absorbs ambient moisture and will agglomerate (cake), which can degrade HPLC assay purity over extended exposures.

Q9
Does guanosine require special customs declarations for export?

No. Guanosine is categorized as a non-hazardous fine chemical raw material, meaning it does not require dangerous goods (DG) transport declarations or specialized hazardous licensing. Standard general cargo declaration procedures apply smoothly across international ports when accompanied by our provided MSDS.

Q10
What downstream products can be synthesized from guanosine powder?

Primary industrial derivatives synthesized directly from our bulk powder include disodium 5’-GMP, GDP disodium, GTP trisodium, cyclic GMP (cGMP), critical APIs like Acyclovir and Valacyclovir, as well as highly specialized modified guanosine biochemical probes and nutrient supplements for premium cell culture media formulations.

Certificate

COA, MSDS, and GMP PDF files are available for download.

Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.

About Guanosine

Guanosine CAS 118-00-3: A Complete Buying Guide for Food & Pharma Raw Material Manufacturers

1. Overview of Guanosine as a Core Purine Nucleoside Raw Material

Procurement managers and R&D engineers from flavor factories, pharmaceutical API plants, and biotech labs constantly search for reliable guanosine suppliers with a stable, high-purity output. Guanosine (CAS number: 118-00-3) is a natural purine nucleoside formed by a guanine base linked to β-D-ribose through an N9 glycosidic bond. It is widely recognized as an irreplaceable upstream intermediate across food and healthcare manufacturing supply chains.

Resolving B2B Supply Pain Points: Many overseas bulk buyers regularly face unstable quality issues from small-scale workshop suppliers. These include fluctuating HPLC purity, excessive heavy metal content, and inconsistent crystallization effects—all of which directly disrupt automated, continuous production lines. Our factory’s decade-long fermentation production line eliminates these common risks through standardized ion-exchange purification and rigorous recrystallization workflows, delivering exceptional batch-consistency for long-term contract clients.

Unlike single-purpose fine chemicals, guanosine carries dual commercial value:

Food-Grade Batches: Serve the global savory seasoning and flavor enhancement industry.
Pharma-Grade Powder: Supports high-yield mass synthesis of critical nucleoside antiviral drugs.

This dual-application adaptability makes guanosine a consistently high-demand bulk raw material across Europe, Southeast Asia, and North America.

2. How Fermentation-Produced Guanosine Outperforms Synthetic Alternatives

Two mainstream manufacturing methodologies supply commercial guanosine to global markets: chemical total synthesis and microbial fermentation. Data reveals that over 90% of medium-to-large manufacturers select fermentation guanosine for long-term bulk procurement due to three definitive structural advantages:

• Zero Toxic Solvent Residues

Chemical synthesis relies heavily on toxic reagents like methylbenzene and chloroform during condensation reactions, leaving trace solvent impurities that are deeply embedded. Fermentation production uses only a glucose aqueous solution as the culture medium, eliminating harmful organic solvent contaminants fundamentally and complying fully with strict EU and Australian safety ceilings.

• Highly Uniform Crystallization

Our specialized bio-fermentation process forms uniform, white crystal particles after hot water recrystallization. This ensures the powder dissolves evenly during phosphorylation reactions to produce GMP. Synthetic alternatives frequently result in uneven dissolution, lowering downstream GMP conversion rates by 5% to 8%.

• Scalable & Dependable Output

Large-scale bio-fermentation lines comfortably support a stable monthly output exceeding 50 metric tons, providing agile scheduling for seasonal spikes. Small chemical synthesis workshops cannot scale output quickly, which often triggers costly logistics delays during peak seasonal ordering cycles.

Common Procurement Trap: Selecting low-priced synthetic guanosine to cut upfront expenditure often results in product rejection by food safety inspection authorities or a reduced yield in finished products, creating larger net operational losses over a 6-month supply cycle.

3. Grade Separation Standards: Match the Grade to Your Production Line

Three distinct industrial grades of guanosine cover all commercial application scopes. Procurement teams must cross-check these strict threshold indicators via the Certificate of Analysis (COA) prior to shipping:

Purity / Specification Grade	Core Target Industry	Primary Technical Metrics
Food Grade	I+G compound umami modifiers, instant noodle seasoning, savory sauces.	HPLC ≥ 98.5%
Pharma Intermediate Grade	Acyclovir, Valacyclovir APIs, GTP injection, cardiovascular auxiliaries.	HPLC ≥ 99.0% (Single Impurity ≤ 0.1%)
Cell Culture Reagent Grade	Biotech R&D labs, university research, in vitro RNA transcription.	HPLC ≥ 99.5% (Nuclease-Free / Sterile)

4. Key Structural Distinctions: Guanosine vs. Inosine vs. Adenosine

To eliminate wrong raw material orders that can halt factory production lines for weeks, verify the structural and application differences outlined below:

Guanosine: Features a distinct C2 amino group on the guanine purine ring. This exact chemical configuration allows for phosphorylation to generate GMP umami nucleotides and guanine-based antiviral drug skeletons. It is completely irreplaceable for these two downstream production pathways.

Inosine: Lacks the critical C2 amino functional group. It is capable only of synthesizing IMP single-flavor agents and lacks antiviral synthesis potential. Substituting inosine to manufacture Acyclovir will result in zero target API generation after a complete reaction cycle.

Adenosine: Utilizes an adenine base framework. It is used primarily for ATP cardiac medicine and laboratory RNA substrates, providing zero contribution to umami flavor amplification profiles.

5. Global Industrial Applications & Buyer Demand Scenarios

• Food Additive Manufacturing

Concentrated among instant food, bouillon cube, and processed meat operations across the Asia-Pacific, EU, and Latin America. The I+G flavor enhancers derived from guanosine drastically multiply natural savory taste perception without adding extra sodium, supporting clean-label and low-sodium food formulations.

• Pharmaceutical API Synthesis

Primarily demanded across premium drug synthesis facilities in India, North America, and Eastern Europe. Because Acyclovir and Ganciclovir remain foundational treatments for herpes and related viral strands, factories rely heavily on consistent, pharma-grade guanosine feedstocks backed by robust regulatory documentation (MSDS, ISO).

• Biotechnology & Diagnostic Assays

Characterized by smaller, ultra-high-purity batches used as cell culture media supplements or diagnostic reagent standards. These technical buyers place high importance on rapid access to matching validation testing reports (NMR, HPLC chromatograms).

6. Four Actionable Sourcing Tips for B2B Purchasing Managers

Cross-Check Trial vs. Bulk COAs: Some trading middlemen supply pristine pre-production evaluation samples but deliver lower-tier bulk lots. Ensure your internal lab verifies that the mass-delivered batch matches the pre-shipment parameters perfectly.
Lock In the Production Route contractually: Always state explicitly in your written purchase contract that the material must be produced via microbial fermentation to legally protect your production line from synthetic contamination.
Verify Export Document Integrity: Confirm the manufacturer can supply a complete export documentation set—including ISO9001, full MSDS, and independent microbiological assays—to avoid lengthy border custom holdups.
Execute a 25kg Drum Trial Run: Before signing comprehensive annual ton-level volume contracts, run a single 25kg trial drum through your machinery to evaluate real-time dissolution speeds and reaction yields.

7. Storage, Packaging & International Shipping Protocols

Standard Packaging Options

R&D Evaluation Samples: 10g to 100g sealed airtight aluminum bottles or 1kg vacuum foil bags.
Standard Bulk Orders: 25kg rugged fiber drums lined with protective double-layer PE inner bags.
High-Volume Consolidation: 1,000kg bulk bags reinforced with palletized stabilization for full container loads (FCL).

Warehouse Storage Guidance

Store unopened guanosine packages within a cool, dry environment maintained consistently below 25°C, safely removed from humid ventilation ducts and direct sunlight. Once the original factory seal is broken, the fine powder will absorb ambient moisture rapidly, causing it to form hard agglomerates (cake) and gradually lowering active HPLC assay purity within 3 months.

International Customs Classification

Guanosine is officially classified as non-hazardous general chemical cargo for all modes of international logistics (sea, air, and overland express freight). No specialized dangerous goods (DG) licensing is required. Our dedicated logistics team securely affixes comprehensive MSDS and COA paperwork externally to every pallet, streamlining customs clearance and minimizing demurrage risks at destination ports.

Secure Your High-Purity Guanosine Supply Chain

Consistent chemical metrics ensure high finished product yields, strict regulatory compliance, and predictable manufacturing margins. Our dedicated fermentation workshop provides flexible sample support, customized packaging, and full compliance documentation for global buyers.

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