Book Appointment Now
CMP-Na₂CAS：6757-06-8
We supply high purity Cytidine 5′-Monophosphate Disodium Salt (5′-CMP·2Na) food grade, pharma grade & bioreagent grade. Enzymatic synthesis, strict HPLC testing, bulk MOQ 1kg–25kg drum. Ideal for infant formula, nucleotide API intermediate, cell culture raw materials, stable low price for global B2B buyers.
| Specification Item | Technical Data & Supply Details |
|---|---|
| Chemical Identifiers | CAS Number: 6757-06-8 | Molecular Formula: C9H12N3O8PNa2 |
| Standard Grades | 🟢 Food Grade: ≥98.0% 🔵 Pharma Grade: ≥99.0% 🟣 Bioreagent Grade: ≥99.5% |
| Production Route | Enzymatic Synthesis (Natural yeast RNA source, guarantees ultra-low single impurities and low heavy metal residues) |
| Core Applications | Infant formula milk powder, liver healthcare supplements, CTP/CDP disodium synthesis intermediates, mammalian cell culture mediums. |
| Standard Packaging | Small Orders: 1kg vacuum aluminum foil bag | Bulk Orders: 25kg sealed moisture-proof fiber drum |
| Compliance & Quality | GB 1903.5 MSDS Batch COA Microbial Test Report |
| MOQ & Discount | Minimum order quantity is 1kg for sample testing. Tiered wholesale price discount available for bulk contract orders over 1,000kg. |
Product Specs
5′-Cytidylic Acid Disodium Salt (5′-CMP·2Na) | Premium Manufacturer Supply
Our 5′-Cytidylic Acid Disodium Salt (5′-CMP Disodium) is produced via advanced yeast RNA enzymatic hydrolysis and directional phosphorylation. With high purity, excellent solubility, and strict heavy metal control, it is widely used in food additives (infant formula), pharmaceutical intermediates, and biochemical reagents.
1. Basic Identification Index
| Common Name: | 5′-Cytidylic Acid Disodium Salt / 5′-CMP Disodium |
| IUPAC Name: | Disodium (2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate |
| Abbreviation / CAS: | 5′-CMP·2Na CAS No: 6757-06-8 |
| Molecular Weight: | Anhydrous: 401.15 | Monohydrate: 419.16 |
| Appearance & Odor: | Odorless white crystalline powder with slight umami taste |
| Solubility: | Freely soluble in purified water; Insoluble in ethanol, acetone, ether |
| Optical Rotation [α]D²⁰: | +26° ~ +32° (2% aqueous solution) |
| pH Value (1% solution): | 7.0–8.5 (Weak alkaline) |
| Stability: | Stable under dry sealed storage. Easily hygroscopic. Hydrolyzes under strong acid, high temperature, or long light exposure. |
2. Grade Separation Quality Standard (HPLC Core Index)
| Test Item | Food Grade (GB1903.5-2016) | Pharmaceutical Intermediate Grade | Biochemical Reagent Grade |
|---|---|---|---|
| Main Content (HPLC) | ≥98.0% | ≥99.0% | ≥99.5% |
| Single Related Nucleotide Impurity | ≤0.5% | ≤0.1% | ≤0.05% |
| Total Nucleotide Impurities | ≤1.5% | ≤0.5% | ≤0.2% |
| Loss on Drying | ≤10.0% | ≤8.0% | ≤6.0% |
| Lead (Pb) Heavy Metal | ≤10mg/kg | ≤5mg/kg | ≤1mg/kg |
| Arsenic (As) | ≤2mg/kg | ≤1mg/kg | ≤0.1mg/kg |
| Free Phosphate | ≤0.3% | ≤0.1% | ≤0.02% |
| Endotoxin | Unrequired | <0.5EU/mg | <0.1EU/mg |
| Microbe Total Plate Count | ≤1000CFU/g | ≤100CFU/g | Sterile optional |
| Pathogen (E.Coli, Salmonella) | Negative | Negative | Negative |
3. Production & Factory Supply Details
Advanced Manufacturing Technology:
Yeast RNA enzymatic hydrolysis + directional phosphorylation + sodium neutralization → activated carbon decolorization → nanofiltration purification → low-temperature crystallization → vacuum drying. Guaranteed no chemical toxic catalyst residue.
Standard Packaging
- Lab Sample: 1g, 5g, 50g vacuum aluminum foil pouch
- Small Batch: 1kg double PE lined vacuum foil bag
- Industrial Bulk: 25kg fiber drum with double inner PE vacuum bag & moisture-proof lid
- Custom Service: 10kg, 50kg ton bag, nitrogen-filled sealed packaging for long sea freight
Storage & Shelf Life Guide
- Long-term Storage: 2–8°C refrigerated, fully sealed, dark, low humidity warehouse (RH < 60%)
- Short-term Storage: Below 25°C, avoid sunlight, do NOT store with acid chemicals
- Transport Classification: Non-dangerous general chemical goods (rainproof & moisture-proof required)
- Shelf Life: 24 months (unopened refrigerated) | 12 months (room temp) | Use within 3 months after opening
Supporting Documents for Global Import
We provide comprehensive document compliance support to ensure smooth customs clearance for B2B buyers worldwide:
COA Full Test Report
MSDS Safety Data Sheet
Production Flow Chart
Food Additive Qualification
Factory Audit Record
Customs Declaration Document
MSDS Safety Data Sheet
Production Flow Chart
Food Additive Qualification
Factory Audit Record
Customs Declaration Document
FAQ
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Complete Buyer Guide to Bulk Cytidine 5′-Monophosphate Disodium Salt (5′-CMP·2Na) for Food, Pharma & Biotech Manufacturing
💡 Quick Summary for B2B Importers
Our Cytidine 5′-Monophosphate Disodium Salt (CAS 6757-06-8) is produced via natural yeast RNA enzymatic hydrolysis—100% free from toxic chemical catalysts. With high bio-compatibility, excellent water solubility, and strict endotoxin control, it serves as the premier choice for global infant formula, antiviral pharmaceutical APIs, and biotech diagnostics.
What Is Cytidine 5′-Monophosphate Disodium Salt & Its Core Biochemical Value
Cytidine 5′-Monophosphate Disodium Salt, widely shortened as 5′-CMP disodium salt, is a critical pyrimidine mononucleotide disodium salt traded globally in premium raw material supply chains.
Registered under CAS No. 6757-06-8, this compound is derived from the enzymatic hydrolysis of yeast ribonucleic acid rather than full chemical synthesis, delivering outstanding biocompatibility suitable for human edible products and pharmaceutical manufacturing scenarios.
Its molecular structure carries one phosphate group linked at the 5′ carbon position of the cytidine ribose ring, and dual sodium ions adjust the aqueous pH to a mild neutral-alkaline range. This intelligently eliminates the strong acid irritation common in free cytidylic acid raw materials.
Dual Core Strategic Values for Global Manufacturers:
- Nutritional & Physiological Activity: Acts as a direct precursor for in-vivo RNA synthesis, supporting intestinal epithelial cell repair, infant nervous system growth, and liver cell regeneration. Many overseas nutrition brands replace synthetic chemical additives with food-grade 5′-CMP disodium due to its stable regulatory approval supported by NCBI biomedical studies under EU, US, and Asian food additive standards.
- Synthetic Intermediate Usability: Serves as the essential starting substrate for enzyme catalytic production of CDP disodium and CTP disodium—two high-value nucleotide raw materials heavily demanded by antiviral drug factories and biotech lab reagent producers worldwide.
⚠️ CRITICAL NOTE: Unlike mixed 2′,3′-cytidylic acid isomers which have limited application ranges and lack biological activity, the 5′-position phosphorylated CMP disodium retains complete biological activity. This is why bulk food factories and pharma intermediate suppliers exclusively require pure 5′-CMP disodium salt when placing bulk procurement orders.
Three Main Industrial Application Scenarios for Bulk 5′-CMP Disodium Salt
Key Standards to Judge Reliable Bulk 5′-CMP Disodium Salt Factory Suppliers
To filter out low-end chemical traders selling mixed isomer cytidylic acid disguised as pure 5′-CMP disodium salt, international buyers should strictly implement these four core factory audit standards:
01
Confirm the Production Technology Route
Qualified premium suppliers adopt yeast RNA enzymatic hydrolysis and directional phosphorylation instead of full chemical processes. Chemical synthesis contains high toxic catalyst residues and heterocyclic impurities. Always ask suppliers to provide a production flow chart and raw yeast material purchase certifications.
02
Check the Complete HPLC Chromatogram COA
Trustworthy factories provide a full HPLC spectrogram with clearly separated single impurity peak data, rather than just simple percentage purity numbers. Focus on a single impurity limit below 0.5% for food grade and below 0.1% for pharmaceutical grade as your core audit index.
03
Verify Full Supporting Import Documents
Ensure the manufacturer can provide a unified batch COA, international standard MSDS, food additive production qualifications, microbial test reports, and customs clearance auxiliary files. Sourcing from traders without self-production facilities risks customs detention during cross-border shipments.
04
Moisture-Proof Bulk Packaging for Maritime Transit
5′-CMP disodium monohydrate easily absorbs moisture and agglomerates during 30–60 days of ocean transport. Reliable manufacturers utilize a double PE inner lining + vacuum aluminum foil layer inside 25kg fiber drums, alongside optional nitrogen-filled sealing for high-humidity tropical destinations.
Global Shipping, Storage & Bulk Order Cost Optimization Tips
📦 Storage Management
- Short-term Stock: Unopened fiber drums store perfectly for 12 months in a cool, dry room below 25°C.
- Long-term Stock: Large manufacturing plants require a 2–8°C refrigerated warehouse to safely extend shelf life to 24 months.
- After Opening: Finish usage within 3 months; refill the residual powder package with nitrogen and seal tight to prevent light-induced degradation and moisture caking. Keep isolated from strong volatile acids.
💰 Cost Control Policies
- Annual Framework Agreements: Place annual orders above 1,000kg to lock in a stable, tiered factory discount, hedging effectively against raw yeast market fluctuations.
- Consolidated Cargo: Combine multiple 5′-nucleotide raw material orders (UMP, GMP, AMP, CTP disodium) in a single shipment to reduce the logistics expense per kilogram.
- Freight Method: Arrange sea freight bulk shipment rather than air express for orders over 500kg to minimize cross-border transport overheads.
Customs Clearance Notice: 5′-CMP disodium belongs to non-dangerous general chemical goods without IMDG (International Maritime Dangerous Goods) certification requirements. Simply prepare our provided COA, MSDS, and factory qualifications in advance to ensure smooth and effortless import declaration procedures across EU, USA, Australia, Southeast Asia, and Middle Eastern buyer markets.
Common Procurement Mistakes B2B Buyers Make When Sourcing 5′-CMP Disodium Salt
- Confusing 5′-Position CMP Disodium with Mixed 2′,3′-Cytidylic Acid Salts
Mixed isomer cytidylic acid lacks bio-activity and cannot be applied to infant formula or downstream pharma intermediate synthesis. Low-cost traders frequently mislabel it. Always audit the HPLC test report to verify the 5′-position main peak proportion before executing mass production orders. - Ignoring the Endotoxin Index for Pharmaceutical & Cell Culture Applications
Buyers focusing solely on the purity percentage number risk receiving high-endotoxin material, resulting in entire downstream batch scrap losses during mammalian cell cultivation or injection compounding. Clearly inform our sales engineering team of your explicit end-use industry to match the correct grade. - Neglecting Moisture-Proof Packaging Configurations for Long-Distance Sea Freight
Purchasing cheap, single-layer plastic bag packaging configurations usually leads to severely agglomerated and degraded caking upon arrival. This requires costly re-purification and extra labor. Always prioritize vacuum foil + double PE lined fiber drums for your maritime logistics.
