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ATP-Na₂ 987-65-5/51963-61-2
Professional Chinese factory supplies high purity ATP disodium anhydrous CAS 987-65-5 and ATP disodium trihydrate CAS 51963-61-2 for pharma raw material, lab research and diagnostic kits. HPLC ≥98%, full COA, low MOQ bulk wholesale.
Product Specs
Adenosine 5′-Triphosphate Disodium (ATP-Na2) — Anhydrous vs Trihydrate
Specifications & Technical Parameters
| Item | ATP Disodium Anhydrous | ATP Disodium Trihydrate (Mainstream Pharma Grade) |
|---|---|---|
| Standard CAS No. | 987-65-5 | 51963-61-2 |
| Full Chemical Name | Adenosine 5′-triphosphate disodium salt anhydrous | Adenosine 5′-triphosphate disodium salt trihydrate |
| Molecular Formula | C₁₀H₁₄N₅Na₂O₁₃P₃ | C₁₀H₂₀N₅Na₂O₁₆P₃ |
| Molecular Weight | 551.15 | 605.19 |
| EINECS Number | 213-579-1 | Matched trihydrate registry |
| Appearance | White crystalline powder, strong moisture absorption | White crystal powder, milder hygroscopicity than anhydrous |
| Solubility | Easily soluble in pure water; insoluble in ethanol, ether, acetone | Same water solubility, better long-term powder stability |
| 1% Aqueous pH | 3.6–5.8 | 4.0–6.0 |
| Decomposition Temp | 176–188℃ | 178–190℃ |
Critical Differences: Anhydrous vs. Trihydrate
- Stability & Logistics: Trihydrate contains crystal water, making it less prone to rapid hydrolysis during long-distance sea transportation. Anhydrous ATP easily absorbs ambient water vapor to form hydrates; it is only suitable for short-term lab use under strict -20℃ sealed storage.
- Dosage Calculation: When preparing molar standard liquids, the molecular weight must be clearly distinguished. 100g of Anhydrous ATP equals approximately 109.8g of Trihydrate in pure ATP effective content. This difference is critical for accurate pharmaceutical formulation dosage calculation.
- Application Matching: Trihydrate is ideal for mass pharmaceutical production and bulk commercial export, whereas Anhydrous is reserved for high-precision lab biochemical testing and academic research kits.
Grade Classification & Purity Standards
1
Pharmaceutical Injection Grade
Trihydrate Dominant: HPLC purity ≥98.0%; ADP ≤1.8%, AMP ≤0.9%, free adenosine ≤0.4%; bacterial endotoxin <0.5EU/mg; heavy metals ≤10ppm. Complies fully with CP pharmacopoeia standards. Primarily used as raw material for ATP injections & oral tablets.
2
Biochemical Research Grade
Anhydrous Preferred: HPLC purity ≥99.0%; DNase/RNase/protease free; ultra-low endotoxin. Perfect for cell culture, enzyme activity assays, P2 receptor research, and high-precision laboratory standard solution preparation.
3
Food & Nutraceutical Grade
Trihydrate: HPLC purity ≥97.0%; microbial limits strictly meet global food raw material standards. Widely used for anti-fatigue sports supplements and bulk nutrition powders.
Main Industrial Application Scenarios
1. Pharmaceutical Active Ingredients (API):
Used in ATP injections, ATP enteric-coated tablets, and compound energy mixture APIs for myocardial injury, nerve rehabilitation, and auxiliary treatment of chronic hepatitis.
2. In Vitro Diagnostic (IVD) Reagents:
Serves as a vital substrate for ATP bioluminescence microbial detection kits and kinase activity testing assays.
3. Biotech & Laboratory Supplies:
Utilized as a mammalian cell culture medium additive and an essential intracellular energy metabolism research reagent.
4. Health & Sports Supplements:
Acts as a premium raw material for endurance sports nutrition powders and anti-fatigue oral functional foods.
Factory Production & Packaging Details
| Lab Package: | 1g, 5g, 10g brown glass vials wrapped with vacuum aluminum foil inner bags. |
| Bulk Package: | 1kg vacuum aluminum foil bags; 25kg cardboard drums with double PE inner liners. |
| Shipping Requirements: | Trihydrate: Shipped under normal temperature sealed transport. Anhydrous: Lab grade shipped via strict ice pack cold chain. |
| Shelf Life & Storage: | Trihydrate: Sealed for 24 months stored at 2–8℃. Anhydrous: Sealed for 36 months stored at -20℃. |
FAQ
Frequently Asked Questions — ATP Disodium Salt Bulk Procurement & Technical Guidance
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
ATP Disodium Anhydrous vs Trihydrate: Full Buying Guide for Pharma & Biotech Bulk Buyers
Quick Summary: Choosing between Anhydrous and Trihydrate ATP Disodium determines your product stability, formulation accuracy, and shipping costs. This definitive B2B sourcing guide covers critical chemical metrics, industrial grading, and factory-level procurement protocols to ensure a zero-loss supply chain.
1. What Is ATP Disodium Salt and Its Core Industrial Value for Global B2B Buyers
Adenosine 5′-triphosphate disodium salt, shortened as ATP-Na₂, is the primary nucleoside triphosphate coenzyme raw material traded across global pharmaceutical and biotech supply chains. As the direct energy carrier inside all eukaryotic cells, ATP disodium acts as an essential raw input for three major commercial sectors: prescription drug manufacturing, in vitro diagnostic kit production, and life science laboratory research.
From our factory’s 10 years of nucleotide export experience, over 75% of overseas bulk buyers are pharmaceutical manufacturers sourcing trihydrate ATP disodium for oral ATP tablets and intravenous energy injection formulas. Conversely, academic labs and high-precision diagnostic enterprises prefer anhydrous ATP disodium for standardized liquid preparation.
⚠️ Costly Sourcing Mistake: Many first-time buyers mix up anhydrous and trihydrate variants without recalculating molecular weight, leading to unstable product purity and customs inspection delays.
Global demand for ATP disodium keeps rising year by year, driven by expanded cardiovascular rehabilitation drug production and the fast-growing microbial bioluminescence detection market. Sourcing precise terms like bulk trihydrate ATP disodium for injection grade and anhydrous ATP disodium lab reagent helps worldwide importers capture reliable raw materials directly from verified manufacturers.
2. Key Chemical & Stability Differences Between ATP Disodium Anhydrous and Trihydrate
The most fundamental gap separating the two ATP disodium variants lies in crystal water content, which completely reshapes molecular weight, storage stability, and industrial applicability.
| Technical Metrics | ATP Disodium Trihydrate | ATP Disodium Anhydrous |
|---|---|---|
| Official CAS Registry | 51963-61-2 | 987-65-5 |
| Molecular Weight | 605.19 (Fixed structure) | 551.15 (Higher initial active content) |
| Hygroscopicity Risk | Mild & Stable; locks water structure | Extreme; triggers hydration within 10 mins |
| Logistics Profile | Excellent for long-distance ocean shipping | Prone to hydrolysis into ADP/AMP if exposed |
| Primary Environment | Mass pharmaceutical mixing workshops | Strictly low-humidity lab settings |
💡 Real B2B Case Study: A European pharma client once purchased anhydrous ATP for tablet production without our technical suggestion; 18% of the batch degraded during 40-day sea transit, causing production line shutdown. After switching to Trihydrate ATP Disodium, their batch degradation rate dropped below 0.3% consistently.
3. Matching ATP Disodium Grades to Different Industrial Application Scenarios
Each ATP variant fits distinct production workflows. Correct grade matching is the core factor B2B buyers must evaluate before placing bulk orders:
1. Pharmaceutical API Production
Trihydrate Only
All mainstream ATP finished medicines (enteric-coated tablets and compound energy injections) require trihydrate API raw materials. Injection-grade batches meet strict endotoxin limits, aligning with global pharmacopoeia benchmarks such as the Chinese Pharmacopoeia (ChP) Standards for nerve rehabilitation and myocardial injury recovery formulas.
2. In Vitro Diagnostic (IVD) Reagent Manufacturing
Dual Grade split
Routine microbial ATP bioluminescence detection kits use trihydrate ATP for low-cost mass production. However, high-sensitivity hormone testing kits for clinical hospital labs adopt anhydrous ATP disodium to guarantee accurate, micro-dose substrate concentrations.
3. Life Science Lab & CRO Research
Anhydrous Preferred
University labs and biotech R&D centers mostly order anhydrous ATP. Researchers conducting cell culture energy metabolism experiments or P2 purinergic receptor screening need anhydrous ATP to prepare zero-impurity standard buffers, as extra crystal water will compromise micro-dose data accuracy.
4. Sports Nutrition & Functional Supplements
Food Grade Trihydrate
Nutraceutical brands exclusively source food-grade trihydrate powder. Its milder hygroscopicity simplifies the physical powder mixing and blending process in mass anti-fatigue oral supplements formulated for endurance athletes.
4. B2B Bulk Purchasing Checklist for ATP Disodium Salt
To avoid purchasing errors, our technical sales team has summarized this 4-point checklist collected from thousands of real ATP global wholesale cases:
- Confirm Production Requirements: Mass commercial drug manufacturing = Trihydrate; High-precision assay kits = Anhydrous. Do not substitute arbitrarily.
- Verify Impurity Limits: Injection production strictly demands low-endotoxin pharma-grade variants; general biology research accepts biochemical grade.
- Clarify Freight Conditions: Ocean container bulk orders must select Trihydrate. Anhydrous lab samples require strict ice-pack cold chain shipping to block immediate hydration.
- Request Compliance Certificates: Always demand a full batch COA (with HPLC chromatogram), SDS safety sheets, heavy metal test reports, and factory ISO certifications.
💰 Pro Sourcing Tip: Order full 25kg trihydrate ATP drums to unlock commercial factory volume discounts. You can also consolidate your container with other nucleotide materials (such as ADP Disodium or UTP Disodium) to minimize ocean freight per kilogram.
5. Standard Storage & Handling Protocols to Extend ATP Disodium Shelf Life
Improper storage is the leading cause of chemical degradation reported by global buyers. Storage rules differ strictly by hydration state:
• Trihydrate ATP Disodium Powder: Keep original vacuum packaging sealed, store in a cool, dry warehouse at 2–8℃, and keep away from sunlight. Unopened drums maintain a 24-month shelf life. Once opened, finish the batch within 90 days or reseal using a nitrogen purge.
• Anhydrous ATP Disodium Powder: Must be kept at a constant temperature of -20℃ with double vacuum aluminum foil packaging. Short-term transportation without a cold chain must not exceed 7 days to avoid weight gain from hydration.
• Crucial Solution Rule: Aqueous ATP solution prepared from either variant cannot sit at room temperature; it hydrolyzes within 3 hours. Working buffers should be prepared fresh daily. Split any surplus liquid into micro-tubes and store at -70℃ for a maximum of 3 months.
6. How to Choose Reliable ATP Disodium Factory Suppliers for Long-Term Cooperation
For pharmaceutical and biotech importers, supplier audit compliance determines supply chain stability. Trustworthy ATP disodium manufacturers should satisfy three core parameters:
- In-House Quality Control Laboratories: The supplier must operate an independent nucleotide production facility equipped with high-performance liquid chromatography (HPLC) capabilities to synthesize both variants in-house rather than outsourcing production.
- Comprehensive Export Certification: The workshop must support complete documentation, including ISO9001 quality system certificates, batch COAs, and SDS to easily clear international customs, complying with regulatory bodies like the U.S. Food and Drug Administration (FDA) and EU raw material import audit rules.
- Flexible Sourcing Support: A reliable partner provides free laboratory test samples, supports small 1kg trial orders before commercial scaling, and offers expert formulation calculation advice.
