Citicoline Sodium CAS:33818-15-4

High purity ≥98% citicoline sodium raw material from China factory, EP/USP standard, bulk & small MOQ for pharma, nutraceutical formulation, free COA available.

Citicoline Sodium (CDP-Choline)

High purity pharmaceutical grade raw material for neuro-support and cognitive supplement formulations.

Item	Specification
Product Name	Citicoline Sodium (CDP-Choline)
Purity	≥98.0% (Dry Base)
Appearance	White crystalline powder
Solubility	Freely soluble in water
Standards	EP / USP / ChP available
MOQ	1–1000 kg
Packaging	1 kg bag / 25 kg drum
Lead Time	3–7 working days

Detailed Information

Citicoline Sodium CAS 33818-15-0 Raw Material Manufacturer & Bulk Supplier

Citicoline Sodium (Cytidine 5′-Diphosphocholine Sodium) CAS 33818-15-0 is a highly purified neuroprotective active ingredient widely used in pharmaceutical formulations, nootropic supplements, veterinary health products, and ophthalmic preparations. As a professional manufacturer, we supply high-purity Citicoline Sodium with stable batch consistency, complete regulatory documentation, and global export support for pharmaceutical and nutraceutical industries.

Why Choose Our Citicoline Sodium?

✔ Pharmaceutical & Nutraceutical Grade Available
✔ HPLC Purity ≥98.0%
✔ USP / EP / Chinese Pharmacopoeia Compliant
✔ Full COA, HPLC Spectrum, MSDS Available
✔ ISO22000, HACCP, HALAL & KOSHER Certified
✔ Global Export Experience to EU, USA & Southeast Asia
✔ Customized Particle Size & Formulation Support

1. Basic Chemical & Physical Specification

Item	Detailed Parameter
Chemical Name	Cytidine 5′-Diphosphocholine Sodium
CAS No.	33818-15-0
Molecular Formula	C₁₄H₂₅N₄NaO₁₁P₂
Molecular Weight	510.31
Appearance	White crystalline powder, odorless
Solubility	Freely soluble in water, insoluble in ethanol, acetone and lipid solvents
Purity Standard	≥98.0% (HPLC), compliant with USP / EP / Chinese Pharmacopoeia 2020
Related Substances	Single impurity ≤0.1%, Total impurities ≤0.5%

2. Pharmacological Core Functions

Neuronal Membrane Repair

Acts as a phosphatidylcholine precursor, supporting neuronal membrane reconstruction after cerebral ischemia, traumatic brain injury, and neurosurgical procedures.

Cognitive Enhancement

Promotes endogenous acetylcholine synthesis and supports memory, learning ability, cognitive performance, and nerve signal transmission.

Brain Energy Metabolism

Enhances ATP production, supports cerebral metabolism, reduces neuronal apoptosis, and assists post-stroke rehabilitation formulations.

3. Main Industrial Applications

Industry	Application
Pharmaceutical API	Citicoline tablets, capsules, injections, stroke rehabilitation drugs, traumatic brain injury medications
Nootropic Supplements	Brain health capsules, cognitive support formulations, anti-aging nutrition products
Veterinary Health	Pet cognitive support products for aging dogs and cats
Ophthalmic Preparations	Optic nerve protection and eye-care formulations

4. Factory Qualification & Supply Advantages

Certifications: ISO22000, HACCP, HALAL, KOSHER and GMP-related production documentation.

Quality Control: Independent third-party testing available before shipment. Each batch is supplied with COA, HPLC chromatogram and supporting quality documents.

Global Logistics: Professional export packaging with complete documentation support for customs clearance in Europe, North America and Southeast Asia.

Customization Service: Customized particle size, formulation assistance, sample development and R&D support for new product projects.

5. Storage & Transportation Conditions

Store in a sealed container away from direct light.
Recommended storage temperature below 25°C.
Keep in a cool, dry and well-ventilated warehouse.
Avoid freezing and excessive humidity exposure.
Do not transport together with strong oxidizing agents or strong acids.
Follow standard chemical cargo handling procedures during shipment.

Request COA, Price & Sample

Looking for a reliable Citicoline Sodium manufacturer and bulk supplier? Contact us today for the latest quotation, COA, specification sheet, sample availability, and customized production solutions.

FAQ

Citicoline Sodium Raw Material FAQ

Key technical and commercial questions about citicoline sodium (CDP-Choline) for pharmaceutical and supplement manufacturing.

Q1: What is the difference between citicoline free acid and citicoline sodium?

Citicoline free acid has very low water solubility and is not suitable for oral or injection formulations.
Citicoline sodium is the standard commercial form with high solubility (≥50g/100ml water), widely used in pharma and nutraceutical production.

Q2: What is the MOQ for citicoline sodium samples?

Sample orders start from 10g to 1kg for lab testing. Bulk production MOQ begins at 25kg, with flexible trial orders for R&D and new formulations.

Q3: Can your citicoline sodium pass FDA and EU customs requirements?

Yes. Each batch is supplied with COA, microbial and heavy metal test reports.
Production follows GMP standards, meeting US FDA and EU REACH import requirements.

Q4: What is the shelf life of citicoline sodium powder?

Shelf life is 24 months in sealed packaging under cool, dry, and dark storage conditions.
Production and expiry dates are clearly marked on each drum.

Q5: Can citicoline sodium be used with levodopa?

Yes. Clinical data suggests citicoline may have a synergistic effect with levodopa.
It is commonly used in Parkinson’s supportive formulations.

Q6: What packaging options are available?

Standard export packaging is 25kg fiber drum with double PE liner.
Small samples use 1kg vacuum aluminum foil bags. Custom packaging is available on request.

Certificate

COA, MSDS, and GMP PDF files are available for download.

Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.

About Citicoline Sodium

How to Select High Quality Citicoline Sodium Raw Material for Pharmaceutical & Supplement Formulation

Citicoline Sodium (CDP-Choline, CAS 33818-15-4) is a pharmaceutical-grade active ingredient widely used in neurological drugs and cognitive health supplements. Selecting a high-quality raw material is critical for ensuring product safety, stability, and regulatory compliance in global pharmaceutical and nutraceutical manufacturing.

1. Core Definition & Biochemical Feature of Citicoline Sodium

Citicoline Sodium is a natural endogenous nucleotide compound synthesized from cytidine and choline via a diphosphate linkage structure. It plays a dual biological role in human metabolism:

Choline donor: Supports acetylcholine synthesis for brain signaling
Cytidine precursor: Promotes phospholipid regeneration in neuronal cell membranes

Compared with choline chloride, Citicoline Sodium demonstrates significantly higher neurological bioactivity and blood-brain barrier permeability, making it a preferred raw material for brain-targeted formulations.

Pharmaceutical-grade citicoline sodium is characterized by:

White crystalline powder appearance
High water solubility
Strict impurity and solvent control
Stable particle uniformity

For procurement teams, HPLC purity verification and COA review are the first mandatory steps before supplier qualification.

2. Industrial Application Fields of Citicoline Sodium

Citicoline Sodium is widely applied across global pharmaceutical, supplement, and healthcare industries. The main application sectors include:

Pharmaceutical APIs: Used in tablets and injections for stroke recovery, traumatic brain injury, dementia, and neurological rehabilitation (EP/USP standards)
Dietary supplements: Cognitive support capsules, memory enhancement formulas, anti-fatigue products
Animal health: Pet cognitive support formulations for aging dogs and cats
Ophthalmic formulations: Eye drops for optic nerve protection and glaucoma-related support

Citicoline Sodium is often compared with Alpha-GPC, but differs in metabolic pathway:

Citicoline Sodium: Direct blood-brain barrier transport
Alpha-GPC: Requires liver metabolism before brain utilization

This is why Citicoline Sodium is widely preferred in hospital-grade neurological medicines.

3. Key Quality Inspection Standards for Bulk Procurement

Professional buyers must strictly evaluate the following quality indicators before bulk purchasing:

HPLC purity: ≥ 98.0%
Related substances: single impurity ≤ 0.1%, total ≤ 0.5%
Residual solvents: compliant with ICH Q3C standards
Heavy metals: ≤ 10 ppm (Pb, As, Cd, Hg controlled)
Microbial limits: total bacteria, yeast, mold within pharmacopeia limits
Solution clarity: fully soluble, transparent aqueous solution

Reliable GMP manufacturers provide full documentation including:

Certificate of Analysis (COA)
HPLC chromatogram
Microbial test reports
Third-party laboratory verification

4. Sample Testing & Bulk Order Procurement Strategy

To minimize procurement risk, global buyers typically follow a staged purchasing model:

Step 1: Request samples with matching pharmaceutical or food-grade specification
Step 2: Confirm COA and batch consistency before lab testing
Step 3: Start with 1–25 kg trial orders for formulation validation

Key procurement considerations:

Confirm MOQ flexibility during R&D stage
Clarify packaging, delivery time, and quality claim policy
Ensure proper Incoterms and documentation for customs clearance

Citicoline Sodium is non-hazardous chemical material and can be shipped via air or sea freight with standard customs documentation.

5. Storage Guidelines for Citicoline Sodium Raw Material

Citicoline Sodium is hygroscopic and sensitive to humidity and heat. Proper storage is essential to maintain product stability.

Store in sealed original packaging
Maintain temperature below 25°C
Relative humidity below 60%
Avoid direct sunlight exposure
Keep away from strong acids and oxidizing agents

After opening:

Transfer to airtight aluminum foil packaging
Minimize air exposure during use

Shelf life under proper storage conditions is typically 24 months.

Conclusion

Selecting high-quality Citicoline Sodium requires strict attention to purity, impurity profile, regulatory compliance, and supplier reliability. For pharmaceutical and supplement manufacturers, working with GMP-certified suppliers and verifying full batch documentation is essential to ensure product safety and market approval success.