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NRHM CAS：2415659-01-5
Nicotinamide Riboside Malate (NRHM) is a premium, highly stable salt form of Nicotinamide Riboside (NR) combined with malic acid. As a nextgeneration NAD+ precursor, it delivers superior stability, low hygroscopicity, and enhanced bioavailability compared to conventional NR chloride (NRCl). Ideal for B2B manufacturing of dietary supplements, skincare, and functional foods.
Key Product Highlights
• CAS No.:
2415659-01-5
• Purity:
≥99.5% (HPLC)
• Stability:
Thermally stable up to 130°C; 2+ year shelf life
• Hygroscopicity:
Ultra-low (≤1% weight gain at RH 75% for 72h)
• Form:
White crystalline powder, free-flowing
• Certifications:
FDA NDI
GRAS
Non-GMO
Gluten-Free
Detailed Information
Technical Specifications
| Item | Specification |
|---|---|
| Chemical Name | Nicotinamide Riboside Malate (NRHM) |
| CAS Number | 2415659-01-5 |
| Molecular Formula | C₁₅H₂₀N₂O₁₀ |
| Molecular Weight | 404.33 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥99.5% |
| Melting Point | 128–132°C |
| Solubility | Freely soluble in water (≥100 mg/mL); soluble in methanol; slightly soluble in ethanol |
| Loss on Drying | ≤0.5% |
| Heavy Metals | ≤10 ppm (Pb ≤2 ppm, As ≤1 ppm) |
Advanced Quality & Stability
✓ Crystal Form
Patented crystalline structure XRD verified
✓ Thermal Stability
No significant degradation after 24h at 100°C
✓ pH Stability
Stable at pH 3–7; dissociates rapidly in gastric fluid
✓ Shelf Life
24 months when stored at ≤25°C (dry, dark, sealed)
Primary Applications (B2B Focus)
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Dietary Supplements
NAD+ boosting, anti-aging, and metabolic support formulations (capsules & tablets).
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Skincare Raw Materials
Anti-photoaging serums and functional creams. Recommended dosage: 0.375–1.5 mg/mL.
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Functional Foods & Sports Nutrition
Premium ingredient for energy drinks, meal replacements, and sports nutrition products.
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Pharmaceutical Intermediates
High-purity research compounds targeting neurodegenerative and metabolic disorders.
Manufacturing & Supply Capabilities
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Advanced Production: One-pot chemical synthesis ensuring precise 1:1 NR-malate salt formation. - •
Scalable Capacity: Multi-ton monthly commercial output. Standard packaging available in 1 kg and 25 kg options. - •
Rigorous Quality Control: Full COA, HPLC, MS, and comprehensive microbial testing provided for every individual batch. - •
Reliable Global Delivery: 5–7 business days for sample validation; 10–15 business days for commercial bulk orders.
FAQ
Nicotinamide Riboside Malate (NRHM) – FAQ
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Nicotinamide Riboside Malate (NRHM) – The Stable High-Purity NAD+ Precursor for B2B Manufacturing
Introduction to Nicotinamide Riboside Malate (NRHM)
Nicotinamide Riboside Malate (NRHM), registered under CAS 2415659-01-5, is a premium stabilized salt form of Nicotinamide Riboside (NR), a key vitamin B3 derivative and vital NAD+ precursor. As cellular NAD+ levels decline with age—driving senescence, metabolic slowdown, and reduced mitochondrial function—demand for reliable NAD+ boosters has surged in the global dietary supplement, skincare, and functional food markets.
Unlike conventional Nicotinamide Riboside Chloride (NR-Cl), which suffers from high hygroscopicity and poor thermal stability, NRHM is engineered for industrial-grade stability, low moisture absorption, and consistent batch purity. This makes it the preferred choice for B2B manufacturers seeking scalable, cost-effective, and high-quality bulk raw materials.
NRHM is produced via a controlled one-pot synthesis that bonds NR with malic acid in a precise 1:1 molar ratio, forming a crystalline salt with a molecular formula of C₁₅H₂₀N₂O₁₀ and a molecular weight of 404.33 g/mol. The result is a white, free-flowing crystalline powder with ≥99.5% purity (HPLC), excellent water solubility (≥100 mg/mL), and ultra-low hygroscopicity (≤1% weight gain at RH 75% for 72h). These optimized properties effectively address critical pain points in factory production—such as clumping, degradation, and short shelf life—while significantly enhancing formulation flexibility.
Key Advantages of NRHM Over Traditional NAD+ Precursors
The global NAD+ supplement market is dominated by three primary precursors: nicotinamide (NAM), nicotinamide mononucleotide (NMN), and Nicotinamide Riboside (NR). While all three boost NAD+ coenzymes, they differ significantly in bioavailability, stability, cost, and formulation compatibility—with NRHM emerging as the most balanced option for commercial B2B applications:
1. Superior Thermal Stability & Storage
NR-Cl, the original NR salt, is highly unstable, requiring cold storage (−20°C) and moisture-proof packaging. In contrast, NRHM is stable at temperatures up to 130°C and retains ≥98% purity after 30 days of air exposure, enabling a 24-month shelf life under ambient conditions (≤25°C). This eliminates costly cold-chain logistics.
2. Ultra-Low Hygroscopicity for Easy Blending
NR-Cl absorbs >15% moisture at RH 75% within 72 hours, causing clumping and inconsistent dosing. NRHM’s ≤1% moisture gain under the same conditions ensures consistent powder flow, uniform blending with active ingredients, and reliable capsule/tablet filling, reducing factory batch rejection rates.
3. Enhanced Bioavailability & Cellular Energy Synergy
NRHM dissociates into NR and malate in vivo. NR enters cells via the NRK pathways, boosting NAD+ 5–10× more efficiently than NAM (which relies on the rate-limiting NAMPT enzyme). Concurrently, malate acts as a natural intermediate in the TCA cycle, synergistically enhancing mitochondrial ATP energy output.
4. High Regulatory Safety Profile
NRHM is acknowledged under the FDA NDI registry with GRAS status. Toxicological data indicates an oral LD50 >5000 mg/kg (practically non-toxic), causing zero skin flushing or gastrointestinal irritation at standard dosages.
Core Applications of NRHM in B2B Manufacturing
NRHM’s unmatched chemical versatility and stability allow seamless integration into three core high-growth global B2B sectors:
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Dietary Supplements
The premier precursor choice for anti-aging, metabolic health, and cognitive formulations. Ideal for direct compression into tablets, hard gel capsule filling, or blending with co-actives like Resveratrol, Pterostilbene, or CoQ10. Recommended dosage: 250–500 mg daily.
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Skincare Raw Materials
Acts as an active anti-photoaging agent that activates SIRT1 and repairs UVA-induced DNA damage in keratinocytes. Its excellent pH stability (pH 3–7) permits trouble-free blending into topical anti-wrinkle serums, facial creams, and sunscreens. Recommended concentration: 0.375–1.5 mg/mL.
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Functional Foods
Perfect for standard functional energy beverages, powder meal replacements, and targeted sports nutrition lines. Its high water solubility (≥100 mg/mL) guarantees completely clear liquids with zero sediment, while its neutral taste profile prevents off-flavors. Dosage: 50–200 mg/serving.
Quality Control & Regulatory Compliance for B2B Buyers
For commercial global procurement, chemical grade verification and compliance are absolutely non-negotiable. Our manufacturing facility implements a strict multi-tier quality control workflow:
- Raw Material Testing: Comprehensive pre-analysis of input NR-Cl and pure DL-malic acid for initial purity, moisture ratios, and heavy metal counts.
- In-Process Monitoring: Strict automated adjustment of reaction temperatures, system pH, and molar profiles to guarantee absolute 1:1 crystalline salt conversion.
- Final Batch Release: Every batch is released with mandatory HPLC (purity ≥99.5%), Mass Spectrometry (MS) for molecular mass, XRD for crystal integrity, and full microbial pathogen screenings.
- Comprehensive Documentation: Full standard Certificate of Analysis (COA), detailed Safety Data Sheets (SDS), and certification documents (FDA NDI, GRAS) accompany every batch shipment.
Why Choose Our NRHM for Your B2B Formulations?
As an established direct manufacturer of commercial-grade NAD+ precursors, we deliver scalable supply chains tailored to international corporate requirements:
- Patented Crystalline Technology: Our unique crystal structure guarantees industry-leading powder flowability and stability, minimizing production dust and waste.
- Multi-Ton Industrial Output: Dependable regular inventory capacity catering seamlessly to early-stage corporate R&D pilots up to full commercial manufacturing.
- Premium Protective Packaging: Standard supply in heavy-duty 1 kg / 25 kg multi-layer aluminum foil moisture-barrier bags and sealed fiber drums.
- Expert Technical Support: In-house formulation engineers provide direct guidance on chemical compatibility, blending, and accelerated shelf stability testing.
- Direct Factory Contract Pricing: Optimized sourcing structure directly from our chemical synthesis floors, bypassing middlemen to secure your corporate bottom-line margins.
Conclusion – NRHM as the Future of NAD+ Precursor Manufacturing
As global market indicators for anti-aging supplements, skin repair materials, and clean-label nutritional products maintain consistent upward trajectories, Nicotinamide Riboside Malate (NRHM) sets the new industry standard for stable NAD+ supplementation. Its excellent physical properties, high crystalline purity, and straightforward global regulatory compliance eliminate the operational limits of historic NR-Cl.
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