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Nicotinamide Riboside Chloride CAS 23111-00-4: Premium NAD+ Precursor for Bulk Supply
A definitive industrial guide on chemical properties, competitive advantages over alternative biochemical substrates, regulatory compliance, and optimization of international wholesale supply chains.
Introduction to Nicotinamide Riboside Chloride (NR-Cl)
Nicotinamide Riboside Chloride (NR-Cl), with CAS number 23111-00-4, is a high-purity vitamin B3 derivative and one of the most effective NAD+ precursors available today. As a specialized chloride salt form of nicotinamide riboside, it offers exceptional stability, solubility, and bioavailability compared to other classic NAD+ boosters such as NMN or niacinamide.
NR-Cl is globally recognized across the nutraceutical, cosmetic, and pharmaceutical industries for its superior capacity to elevate intracellular NAD+ levels, supporting mitochondrial energy metabolism, enzymatic DNA repair, and systemic healthy aging pathways. For B2B buyers, securing high-quality, factory-direct bulk NR-Cl powder is a critical requirement for manufacturing premium dietary supplements, advanced skincare matrices, and reliable laboratory research materials.
Chemical Properties and Specifications of NR-Cl CAS 23111-00-4
NR-Cl possesses the molecular formula C₁₁H₁₅ClN₂O₅ and a defined molecular weight of 290.70 g/mol. Physically, it presents as a white to off-white crystalline powder that is completely odorless, ensuring seamless blending and formulation versatility across diverse product delivery systems.
| Technical Parameter | Certified Factory Standards |
|---|---|
| Purity (HPLC) | Standard Grade: ≥98.0% | Premium Grade: ≥99.0% |
| Physical Thresholds | Melting Point: 128–130 °C (Decomp.) | Moisture (Karl Fischer): ≤2.0% |
| Solubility Profile | 10 mg/mL in water (clear, colorless solution); highly soluble in DMSO; slightly soluble in ethanol. |
| Heavy Metals | Lead (Pb) ≤0.1 ppm | Arsenic (As) ≤1.0 ppm | Mercury (Hg) ≤0.1 ppm | Cadmium (Cd) ≤0.2 ppm |
| Residual Solvents | Acetone ≤5000 mg/kg | Methanol ≤1000 mg/kg | Acetonitrile ≤50 mg/kg |
| Microbiological Assay | Total Plate Count: ≤100 CFU/g | Pathogens: Completely Absent / Negative |
Its engineered crystalline chloride salt structure ensures superior thermal and physical stability during processing. Bulk orders preserve full biochemical activity for a guaranteed 24-month shelf life when stored properly under sealed conditions at 2–8 °C, kept strictly dry, and shielded from light exposure.
How NR-Cl Works: NAD+ Precursor and Cellular Benefits
Nicotinamide Adenine Dinucleotide (NAD+) is a vital life-sustaining coenzyme involved in over 500 downstream cellular processes, including metabolic energy generation, deep DNA repair, sirtuin enzyme activation, and comprehensive antioxidant defense. Because internal NAD+ pools naturally decline with age, metabolic efficiency drops, leading to oxidative stress and cellular aging.
NR-Cl acts as a highly direct, fast-acting NAD+ precursor. Upon cellular uptake, it efficiently converts into NMN and subsequently into active NAD+ in vivo, entirely bypassing baseline rate-limiting enzymatic steps. This optimized pathway delivers clear, clinically backed cellular results:
- Enhanced Energy Metabolism: Maximizes mitochondrial respiratory chains and intracellular ATP generation.
- Sirtuin Activation: Upregulates anti-aging pathways, structural DNA repair mechanisms, and biological stress resistance.
- Metabolic Optimization: Supports weight-management profiles and enhances cellular insulin sensitivity.
- Advanced Cosmeceutical Action: Clinically fuels dermal cell rejuvenation, boosts systemic collagen synthesis, and actively mitigates fine lines.
Key Advantages of NR-Cl Over Other NAD+ Precursors
For mass manufacturing, NR-Cl offers a demonstrably superior commercial profile compared to NMN, standard nicotinamide, or nicotinic acid:
1. Superior Processing Stability: Unlike NMN powder, which is highly prone to humidity-induced degradation, the crystallized chloride salt matrix of NR-Cl actively resists atmospheric breakdown during commercial mixing and long-term storage.
2. Exceptional Bioavailability: It bypasses extracellular phosphorylation barriers, outperforming niacinamide and nicotinic acid by raising systemic tissue coenzyme counts with minimal waste or secondary flushing side-effects.
3. Higher Formulation Solubility: Dissolving smoothly at 10 mg/mL in pure water, it provides a crystal-clear, colorless profile ideal for advanced skincare serums, liquid shots, and instant oral beverage powders.
4. Reduced Global Regulatory Risks: It is fully GRAS-listed (Generally Recognized as Safe) within the United States FDA frameworks and approved under strict Novel Food guidelines inside the European Union, minimizing compliance barriers for multinational brands.
B2B Applications of Nicotinamide Riboside Chloride
Because of its high regulatory compliance and clear chemical advantages, bulk NR-Cl is seamlessly funneled into several high-yield market sectors:
- Dietary Supplements: Formulated into premium standalone longevity capsules, cellular energy tablets, and immune support powder blends with typical clinical dosages ranging between 300 mg to 1000 mg daily.
- Cosmetics & Skincare: Utilized as a high-end bioactive in topical anti-wrinkle matrices, clinical brightening creams, and skin repair serums due to its deep cellular antioxidant properties.
- Pharmaceutical Intermediates: Sourced as a validated laboratory reagent for cell survival assays, sirtuin mapping, and therapeutic drug research targeting age-related neurological and metabolic syndrome models.
- Nutraceutical Functional Foods: Increasingly integrated into premium functional energy bars, protein shakes, and fortified wellness beverages.
Quality Assurance and Bulk Supply for B2B Buyers
We operate fully certified GMP and ISO 9001:2015 manufacturing facilities, guaranteeing absolute batch-to-batch structural consistency and verifiable chemical safety. Every production lot undergoes rigorous liquid chromatography (HPLC) and heavy metal testing before clear-to-ship validation.
B2B Supply Chain Logistics:
• Monthly Production Capacity: 500 kg stable bulk capacity.
• Packaging Standards: 1 kg moisture-barrier aluminum foil bags | 25 kg robust fiber drums with inner food-grade PE liners. Full OEM/ODM private labeling supported.
• Wholesale Lead Times: Fast-tracked dispatch in 5–7 days for pilot validation samples; 10–15 days for full commercial scale contracts.
Conclusion: Partner with a Verified NR-Cl Manufacturer
Nicotinamide Riboside Chloride (NR-Cl) CAS 23111-00-4 represents a premier, legally compliant, and highly bioavailable substrate for forward-looking brands aiming to lead the global longevity and clinical wellness sectors.
✔ Contact our commercial procurement team today to request independent third-party test reports, review current tiered wholesale volume pricing, or secure an official 10g–50g factory sample for internal laboratory verification.
