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Citicoline CAS:987-78-0
Factory direct supply high purity Citicoline raw material CAS987-78-0, white crystalline powder for pharma injection, nootropic supplement & neurological formulation, full COA & global certification, bulk wholesale & small sample available。
| Citicoline Free Base (CAS: 987-78-0) | |
| Purity | ≥ 99.0% (HPLC), Compliant with USP/EP Standards |
| Application | Pharmaceutical API, Cognitive Dietary Supplement |
| Formulation | Tablet, Capsule, Oral Liquid, Injectable |
| Certification | GMP Factory, COA/MSDS/Test Reports Available |
| MOQ & Package | 1kg (Sample), 25kg Drum, Custom Packaging |
Detailed Information
Citicoline (CDP-Choline) CAS 987-78-0
High Purity Citicoline Raw Material for Pharmaceutical, Dietary Supplement & Nootropic Formulations
Basic Chemical Information
| INCI Name | Citicoline |
| Alias | CDP-Choline, Cytidine Diphosphate Choline |
| CAS Number | 987-78-0 |
| Sodium Salt CAS | 33818-15-4 |
| Molecular Formula | C₁₄H₂₆N₄O₁₁P₂ |
| Molecular Weight | 488.33 g/mol |
| EINECS | 213-580-7 |
Key Features
- ≥99.0% HPLC Purity
- Enzymatic Synthesis Technology
- Excellent Water Solubility
- Low Impurity Profile
- GMP Workshop Manufacturing
- Stable Batch Consistency
- Global B2B Bulk Supply
- Suitable for Pharma & Supplement Production
Physical & Chemical Properties
| Property | Specification |
|---|---|
| Appearance | White or Off-White Crystalline Powder |
| Odor | Odorless |
| Hygroscopicity | Strong Hygroscopicity |
| Water Solubility | Freely Soluble in Purified Water |
| Organic Solvent Solubility | Insoluble in Ethanol, Acetone & Non-Polar Solvents |
| pH (1% Solution) | 2.8 – 3.6 |
| Thermal Property | Decomposition Above 185℃ |
| UV Absorption Peak | 271nm (HPLC Identification) |
Quality Specification
Factory Release Quality Control Standards for Global B2B Procurement
Production Standard
- Advanced Enzymatic Synthesis Process
- Low By-Product Formation
- Excellent Process Stability
- Consistent Batch-to-Batch Quality
- GMP Cleanroom Manufacturing Environment
- Suitable for Large-Scale Industrial Procurement
Storage & Shelf Life
- Vacuum Sealed Packaging Recommended
- Store at 2–8℃ in Dry & Dark Environment
- Avoid Moisture, Direct Sunlight & Heat Exposure
- Shelf Life: 24 Months Under Recommended Conditions
- Aqueous Solutions Should Be Stored Below -20℃ for Short-Term Preservation
Why Choose Our Citicoline Raw Material?
Our Citicoline (CDP-Choline) is manufactured through advanced enzymatic synthesis technology, delivering high purity, low impurity levels, excellent water solubility, and stable batch consistency. The product is widely applied in pharmaceutical formulations, nootropic supplements, cognitive health products, and functional nutrition manufacturing. Complete documentation including COA, specification sheets, and quality certificates can be supplied to support international registration and procurement requirements.
FAQ
Frequently Asked Questions About Citicoline CAS 987-78-0
Q1. What is the difference between Citicoline CAS 987-78-0 Free Base and Citicoline Sodium CAS 33818-15-4?
Citicoline CAS 987-78-0 is the free inner salt form of citicoline, commonly selected for laboratory research applications and high-end customized nootropic formulations requiring exceptional purity.
Citicoline Sodium CAS 33818-15-4 offers significantly higher water solubility and is widely utilized as a pharmaceutical-grade API for injectable and oral drug production.
Most pharmaceutical manufacturers choose the sodium form for large-scale commercial production, while premium supplement brands often prefer CAS 987-78-0 for customized cognitive health formulations.
Q2. What MOQ do you offer for bulk Citicoline CAS 987-78-0 purchases?
Our factory supports flexible purchasing quantities for both R&D and commercial production:
- Trial Order: 1kg
- Free Sample: Up to 50g
- Standard Bulk Order: 25kg/drum
- Volume Discount: Available for orders above 100kg
This flexible MOQ policy helps supplement brands and pharmaceutical companies in evaluating product quality before large-scale procurement.
Q3. What certifications can you provide for Citicoline import clearance?
To facilitate smooth customs clearance and regulatory compliance, we provide complete documentation packages including:
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- ISO22000 Certification
- GMP Manufacturing Certificate
- KOSHER Certification (Optional)
- HALAL Certification (Optional)
Our documentation package supports import registration and regulatory requirements across the United States, Europe, Southeast Asia, and other international markets.
Q4. How should bulk Citicoline powder be stored after delivery?
Citicoline is highly hygroscopic and requires proper storage conditions to maintain stability and purity.
- Store in original sealed packaging.
- Maintain temperature at 2–8°C.
- Keep in a cool, dry environment.
- Avoid exposure to humidity during production handling.
- After opening, consume within 3 months whenever possible.
- For long-term use, transfer into nitrogen-protected sealed containers.
Q5. What is the recommended dosage of Citicoline in nootropic formulations?
The recommended dosage depends on the finished product category:
| Application Typical | l Dosage |
|---|---|
| Capsules & Tablets | 250 mg–1000 mg per serving |
| Functional Beverages | 100 mg–300 mg per serving |
| Pharmaceutical Preparations | According to local pharmacopoeia standards |
Our technical team can provide formulation recommendations and dosage references based on your target market and product positioning.
Q6. Can you provide OEM and private label packaging services?
Yes. We offer comprehensive OEM and private-label solutions for supplement brands and distributors worldwide.
- Customized inner bag printing
- Private label drum stickers
- OEM packaging design
- Custom carton labeling
- Repacking services
- Export-ready logistics support
Minimum quantity for customized packaging: 100kg per production batch.
Need Bulk Citicoline Supplier Support?
We provide pharmaceutical-grade and supplement-grade Citicoline raw materials with stable supply capability, complete regulatory documentation, OEM customization services, and worldwide export experience.
✔ CAS 987-78-0 Free Base
✔ Citicoline Sodium CAS 33818-15-4
✔ GMP & ISO Manufacturing
✔ Free Samples Available
✔ OEM / Private Label Support
✔ Global Shipping Service
Certificate
COA, MSDS, and GMP PDF files are available for download.
Ensure quality compliance for pharmaceutical, biotechnology, and cosmetic applications.
Citicoline CAS 987-78-0 Raw Material: Complete Sourcing Guide for Global Pharma & Supplement Manufacturers
Global pharmaceutical manufacturers and nutraceutical brands continuously seek reliable Citicoline CAS 987-78-0 suppliers capable of delivering stable purity, batch consistency, and international compliance. As a key endogenous nootropic ingredient widely used in neurological health products, Citicoline Free Base offers unique formulation advantages compared with Citicoline Sodium (CAS 33818-15-4).
This sourcing guide covers chemical characteristics, commercial applications, quality control standards, supplier evaluation criteria, and bulk purchasing strategies for global B2B buyers.
Quick Facts of Citicoline CAS 987-78-0
| Item | Specification |
|---|---|
| Product Name | Citicoline Free Base |
| CAS Number | 987-78-0 |
| Synonyms | CDP-Choline, Cytidine Diphosphate Choline |
| Molecular Formula | C14H26N4O11P2 |
| Molecular Weight | 488.33 g/mol |
| Appearance | White to Off-White Powder |
| Purity | ≥99.0% (HPLC) |
| Main Applications | Dietary Supplements, Pharmaceutical Formulations, Research Use |
| Packaging | 1kg Bag / 25kg Fiber Drum |
Table of Contents
- Core Chemical Characteristics
- Commercial Applications
- Quality Control Standards
- How to Select a Reliable Supplier
- Bulk Purchasing Tips
- Future Market Trends
- Frequently Asked Questions
1. Core Chemical Characteristics of Citicoline CAS 987-78-0
Citicoline CAS 987-78-0 refers to Cytidine 5′-Diphosphocholine Free Inner Salt, a naturally occurring nucleotide compound involved in phospholipid biosynthesis within mammalian cells.
Compared with Citicoline Sodium (CAS 33818-15-4), the free-base form exhibits:
- Lower water solubility
- Stronger hygroscopicity
- Slower dissolution profile
- Better suitability for sustained-release oral formulations
Our manufacturing process utilizes advanced enzymatic synthesis combined with membrane purification technology to control related impurities below 1%, allowing final purity levels to reach ≥99.0% by HPLC.
Citicoline Free Base vs Citicoline Sodium
| Parameter | Citicoline Free Base | Citicoline Sodium |
|---|---|---|
| CAS Number | 987-78-0 | 33818-15-4 |
| Water Solubility | Moderate | High |
| Primary Application | Capsules & Tablets | Injection API |
| Moisture Sensitivity | Higher | Lower |
| Release Profile | Sustained | Rapid |
2. Main Commercial Applications of Citicoline CAS 987-78-0
Premium Nootropic Supplements
Citicoline Free Base is widely incorporated into cognitive support supplements targeting memory, focus, learning performance, and healthy aging consumers.
- Capsules
- Tablets
- Powder blends
- Functional beverage premixes
Typical dosage ranges between 250mg and 500mg per serving.
Biotechnology Research
Research institutions and biotech laboratories use Citicoline as a neuronal cell culture additive and neurodegenerative disease research material.
Specialized Pharmaceutical Formulations
Selected oral pharmaceutical products utilize Citicoline Free Base for neurological support applications, while injectable products generally rely on Citicoline Sodium due to superior aqueous solubility.
3. Key Quality Control Standards
Before selecting a Citicoline supplier, procurement teams should verify the following quality indicators.
Purity Requirements
- HPLC Purity ≥99.0%
- Complete impurity profile disclosure
- Third-party laboratory verification
Microbiological Standards
- Total Aerobic Count <1000 CFU/g
- Yeast & Mold Compliance
- Pathogen-Free Testing
Heavy Metal Limits
- Total Heavy Metals <10 ppm
- Lead
- Cadmium
- Mercury
- Arsenic
Packaging Validation
Due to strong moisture absorption properties, high-quality Citicoline suppliers should provide:
- Double-layer PE inner bags
- Aluminum foil vacuum sealing
- Fiber drum protection
- Moisture barrier transportation packaging
4. How to Select a Reliable Citicoline Manufacturer
Qualified Citicoline manufacturers should provide:
- GMP Certification
- ISO Quality Management System
- Complete COA Documentation
- MSDS Availability
- Batch Traceability Records
- Third-Party Testing Reports
- Stable Annual Production Capacity
Long-term supplier stability is often more important than achieving the lowest unit price.
5. Bulk Purchasing Tips for Global Importers
Request Trial Samples First
Begin with a 1kg sample evaluation to verify compatibility with your formulation and quality requirements.
Use Volume-Based Pricing Negotiation
Annual contracts above 100kg often receive significant pricing advantages compared with spot purchases.
Verify Import Documents Early
- COA
- MSDS
- GMP Certificate
- HALAL Certificate
- KOSHER Certificate
Establish Quality Compensation Terms
Clear after-sales agreements reduce financial risk associated with purity deviations, packaging failure, or transportation damage.
6. Future Market Trend of Citicoline Free Base
Growing global demand for cognitive health products, healthy aging solutions, and neurological support supplements continues to drive Citicoline market expansion.
Emerging application areas include:
- Brain health beverages
- Nootropic drink powders
- Healthy aging formulations
- Sports cognition products
- Personalized nutrition supplements
At the same time, increasingly strict global regulatory requirements are accelerating industry consolidation, favoring GMP-certified manufacturers with validated production systems.
Frequently Asked Questions
What is Citicoline CAS 987-78-0 used for?
Citicoline Free Base is mainly used in cognitive health supplements, neurological formulations, and biotechnology research applications.
What is the difference between Citicoline Free Base and Citicoline Sodium?
Citicoline Free Base offers lower water solubility and is commonly used in oral dosage forms, while Citicoline Sodium is preferred for injectable pharmaceutical formulations.
What purity level should pharmaceutical-grade Citicoline reach?
Most pharmaceutical and premium supplement manufacturers require HPLC purity of 99.0% or higher.
How should Citicoline be stored?
Store in a cool, dry environment away from moisture and direct sunlight using sealed packaging.
Request Factory Direct Quotation
We provide high-purity Citicoline CAS 987-78-0 manufactured under strict quality management systems with complete export documentation support.
Contact our technical sales team today to obtain:
- Free Trial Sample
- Latest COA
- MSDS Documentation
- Customized Formulation Support
- Factory Direct Bulk Pricing
